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Article

Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering

1
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA
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Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Biomedical Sciences Building JG-53, P.O. Box 116131, Gainesville, FL 32611, USA
3
Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Anthony Guiseppi-Elie
Bioengineering 2015, 2(1), 15-34; https://doi.org/10.3390/bioengineering2010015
Received: 28 October 2014 / Accepted: 12 January 2015 / Published: 14 January 2015
(This article belongs to the Special Issue Biofabrication)
Tissues in the body are hierarchically structured composite materials with tissue-specific chemical and topographical properties. Here we report the preparation of tissue scaffolds with macroscopic pores generated via the dissolution of a sacrificial supramolecular polymer-based crystal template (urea) from a biodegradable polymer-based scaffold (polycaprolactone, PCL). Furthermore, we report a method of aligning the supramolecular polymer-based crystals within the PCL, and that the dissolution of the sacrificial urea yields scaffolds with macroscopic pores that are aligned over long, clinically-relevant distances (i.e., centimeter scale). The pores act as topographical cues to which rat Schwann cells respond by aligning with the long axis of the pores. Generation of an interpenetrating network of polypyrrole (PPy) and poly(styrene sulfonate) (PSS) in the scaffolds yields electroactive tissue scaffolds that allow the electrical stimulation of Schwann cells cultured on the scaffolds which increases the production of nerve growth factor (NGF). View Full-Text
Keywords: electroactive polymers; microfabrication; nerve guide; peripheral nerve; plastic electronics; topography electroactive polymers; microfabrication; nerve guide; peripheral nerve; plastic electronics; topography
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MDPI and ACS Style

Hardy, J.G.; Cornelison, R.C.; Sukhavasi, R.C.; Saballos, R.J.; Vu, P.; Kaplan, D.L.; Schmidt, C.E. Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering. Bioengineering 2015, 2, 15-34. https://doi.org/10.3390/bioengineering2010015

AMA Style

Hardy JG, Cornelison RC, Sukhavasi RC, Saballos RJ, Vu P, Kaplan DL, Schmidt CE. Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering. Bioengineering. 2015; 2(1):15-34. https://doi.org/10.3390/bioengineering2010015

Chicago/Turabian Style

Hardy, John G., R. C. Cornelison, Rushi C. Sukhavasi, Richard J. Saballos, Philip Vu, David L. Kaplan, and Christine E. Schmidt 2015. "Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering" Bioengineering 2, no. 1: 15-34. https://doi.org/10.3390/bioengineering2010015

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