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Bioengineering
Volume 12
Issue 8
10.3390/bioengineering12080883
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Dynamic Behavior of the Stenting & Shielding Hernia System Fosters Neomyogenesis in Experimental Porcine Model

by
Giuseppe Amato
1,*,
Roberto Puleio
2,
Antonino Agrusa
1,
Vito Rodolico
3,
Luca Cicero
4,
Giovanni Cassata
4,
Giuseppe Di Buono
1,
Emanuele Battaglia
1,
Claudia Neto
5,
Giorgio Romano
5,
William Ra
5 and
Giorgio Romano
1
1
Department of Precision Medicine in Medical, Surgical and Critical Areas, University of Palermo, 90127 Palermo, Italy
2
Department of Pathologic Anatomy and Histology, Istituto Zooprofilattico Sperimentale della Sicilia (IZSS Palermo), 90129 Palermo, Italy
3
Department PROMISE, Section Pathological Anatomy, University of Palermo, 90127 Palermo, Italy
4
CEMERIT—Experimental Zooprophylactic Institute of Sicily Palermo, 90129 Palermo, Italy
5
Postgraduate School of General Surgery, University of Palermo, 90127 Palermo, Italy
*
Author to whom correspondence should be addressed.
Bioengineering 2025, 12(8), 883; https://doi.org/10.3390/bioengineering12080883
Submission received: 22 May 2025 / Revised: 3 July 2025 / Accepted: 18 August 2025 / Published: 19 August 2025
(This article belongs to the Section Nanobiotechnology and Biofabrication)
Versions Notes

Abstract

Despite significant advancements, prosthetic hernia repair continues to face unacceptably high complication rates. These likely stem from poor biological responses, such as stiff scar tissue leading to mesh shrinkage. To overcome these issues, the Stenting and Shielding (S&S) Hernia System, a newly designed 3D dynamic device, has been developed for dissection-free laparoscopic placement to permanently obliterate hernia defects. Unlike conventional meshes, this device induces a regenerative biological response, promoting viable tissue growth rather than fibrotic plaque formation. In a porcine experimental model, the S&S device demonstrated the development of a great amount of muscle fibers, alongside nervous and vascular structures, within well-perfused connective tissue. Histological analysis of biopsy specimens excised from the experimental animals revealed progressive muscle fiber maturation from early myocyte development in the short term to fully developed muscle bundles in the long term. The enhanced biological response observed with the S&S device suggests a promising shift in hernia repair, potentially reversing the degenerative processes of hernia formation and promoting tissue regeneration. The S&S Hernia System described here can be classified not merely as a conventional hernia implant, but as part of a new category of hernia devices: the dynamic regenerative scaffold.
Keywords: hernia; regenerative scaffolds; tissue regeneration; neo-myogenesis; experimental research hernia; regenerative scaffolds; tissue regeneration; neo-myogenesis; experimental research

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MDPI and ACS Style

Amato, G.; Puleio, R.; Agrusa, A.; Rodolico, V.; Cicero, L.; Cassata, G.; Di Buono, G.; Battaglia, E.; Neto, C.; Romano, G.; et al. Dynamic Behavior of the Stenting & Shielding Hernia System Fosters Neomyogenesis in Experimental Porcine Model. Bioengineering 2025, 12, 883. https://doi.org/10.3390/bioengineering12080883

AMA Style

Amato G, Puleio R, Agrusa A, Rodolico V, Cicero L, Cassata G, Di Buono G, Battaglia E, Neto C, Romano G, et al. Dynamic Behavior of the Stenting & Shielding Hernia System Fosters Neomyogenesis in Experimental Porcine Model. Bioengineering. 2025; 12(8):883. https://doi.org/10.3390/bioengineering12080883

Chicago/Turabian Style

Amato, Giuseppe, Roberto Puleio, Antonino Agrusa, Vito Rodolico, Luca Cicero, Giovanni Cassata, Giuseppe Di Buono, Emanuele Battaglia, Claudia Neto, Giorgio Romano, and et al. 2025. "Dynamic Behavior of the Stenting & Shielding Hernia System Fosters Neomyogenesis in Experimental Porcine Model" Bioengineering 12, no. 8: 883. https://doi.org/10.3390/bioengineering12080883

APA Style

Amato, G., Puleio, R., Agrusa, A., Rodolico, V., Cicero, L., Cassata, G., Di Buono, G., Battaglia, E., Neto, C., Romano, G., Ra, W., & Romano, G. (2025). Dynamic Behavior of the Stenting & Shielding Hernia System Fosters Neomyogenesis in Experimental Porcine Model. Bioengineering, 12(8), 883. https://doi.org/10.3390/bioengineering12080883

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