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Arctium lappa Extract Suppresses Inflammation and Inhibits Melanoma Progression

Centro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, Brazil
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (FCFRP-USP), Avenida do Café, s/n, 14040-903 Ribeirão Preto, São Paulo, Brazil
Author to whom correspondence should be addressed.
Medicines 2019, 6(3), 81;
Received: 29 June 2019 / Revised: 18 July 2019 / Accepted: 25 July 2019 / Published: 29 July 2019
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Background: Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from A. lappa have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects of A. lappa hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. Methods: The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide. Results: Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival. Conclusions: Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression. View Full-Text
Keywords: Arctium lappa; natural product; phytomedicine; inflammation; melanoma Arctium lappa; natural product; phytomedicine; inflammation; melanoma

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nascimento, B.A.C.; Gardinassi, L.G.; Silveira, I.M.G.; Gallucci, M.G.; Tomé, M.A.; Oliveira, J.F.D.; Moreira, M.R.A.; Meirelles, A.F.G.; Faccioli, L.H.; Tefé-Silva, C.; Zoccal, K.F. Arctium lappa Extract Suppresses Inflammation and Inhibits Melanoma Progression. Medicines 2019, 6, 81.

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