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CO2 Transoral Laser Microsurgery in Benign, Premalignant and Malignant (Tis, T1, T2) Lesion of the Glottis. A Literature Review

Otorhinolaryngology—Head & Neck surgery Department, Hospital Universitario Donostia, 20014 San Sebastian—Donostia, Spain
Biodonostia Health Research Institute, 20014 San Sebastian—Donostia, Spain
Otorhinolaryngology—Head and Neck Surgery Department, Complexo Hospitalario Universitario Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain
Clinical Research in Medicine, International Center for Doctorate and Advanced Studies (CIEDUS), Universidade de Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain
Otorhinolaryngology—Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain
Author to whom correspondence should be addressed.
Medicines 2019, 6(3), 77;
Received: 26 May 2019 / Revised: 16 July 2019 / Accepted: 18 July 2019 / Published: 22 July 2019
(This article belongs to the Special Issue Innovative Laser Medicine and Traditional Acupuncture Therapy)
PDF [2522 KB, uploaded 22 July 2019]


Carbon Dioxide transoral laser microsurgery represents a reliable option for the treatment of early glottic carcinoma (Tis–T2), with good functional and oncological outcomes, nowadays representing one of the main options in larynx preservation protocols. The development and improvement of laser devices means surgeons are able to use more precise instruments compared with classic cold dissection in laser-assisted phonosurgery. Secondary effects on voice, swallowing, or quality of life as well as complications have been well documented. Also, with the introduction of a new proposal for staging systems following the principle of the three-dimensional map of isoprognostic zones, the use of narrow-band imaging in clinical evaluation and intraoperative, and the implementation of diffusion-weighted magnetic resonance during preoperative evaluation, the development of new tools to improve surgical quality and preliminary reports regarding the use of carbon dioxide laser in transoral robotic surgery suggests an exciting future for this technique. View Full-Text
Keywords: glottis; CO2; laser; surgery glottis; CO2; laser; surgery

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Chiesa-Estomba, C.M.; González-García, J.A.; Larruscain, E.; Calvo-Henríquez, C.; Mayo-Yáñez, M.; Sistiaga-Suarez, J.A. CO2 Transoral Laser Microsurgery in Benign, Premalignant and Malignant (Tis, T1, T2) Lesion of the Glottis. A Literature Review. Medicines 2019, 6, 77.

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