Next Article in Journal
Greater Height Is Associated with a Larger Carotid Lumen Diameter
Previous Article in Journal
Evidence for Anti-Inflammatory Activity of Isoliquiritigenin, 18β Glycyrrhetinic Acid, Ursolic Acid, and the Traditional Chinese Medicine Plants Glycyrrhiza glabra and Eriobotrya japonica, at the Molecular Level
Open AccessCase Report

Immunomodulatory Changes Following Isolated RF Ablation in Colorectal Liver Metastases: A Case Report

1
Department of Immunology, Tbilisi State Medical University, 0186 Tbilisi, Georgia
2
Department of Surgery and Cancer, Imperial College London, London W120HS, UK
3
General, Emergency and Robotic Surgery Unit, San Francesco Hospital, 08100 Nuoro, Italy
4
Department of Interventional Radiology, Tbilisi State Medical University, 0144 Tbilisi, Georgia
*
Authors to whom correspondence should be addressed.
Medicines 2019, 6(2), 56; https://doi.org/10.3390/medicines6020056
Received: 10 April 2019 / Revised: 6 May 2019 / Accepted: 7 May 2019 / Published: 13 May 2019
  |  
PDF [2653 KB, uploaded 13 May 2019]
  |  

Abstract

Background: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths in developed countries. The liver is the most prevalent site of metastasis from CRC. Currently, the gold-standard treatment for colorectal liver metastases (CLMs) is surgical resection. However, depending on the pattern of the disease, a significant number of patients may require different approaches alone or in combination with surgery, including thermal ablation (radiofrequency (RFA) or microwave (MWA) ablation) or transarterial liver-directed therapies, although the latter is not yet part of the standard treatment for CRC liver metastases. Methods and Results: We present the case of a 63-yearold man with bilobar CLM who was treated with transarterial embolization (TAE) and RFA followed by chemotherapy. A post-RFA study of immune parameters revealed the downregulation of CD39 expression in the circulating CD4+ T cell population and a reduction of the serum levels of cytokines IL-10, TGF-β, IFN-gamma and IL-17, which positively correlated with the diminished serum level of gamma-glutamyl transferase (GGT) and the subdued inflammatory markers: the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). Later, the patient underwent chemotherapy. Liver failure developed within two years and nine months following tumour ablation, leading to the death of the patient. Conclusions: However, the denial of adjuvant chemotherapy by the patient gave us the opportunity to assess the immunomodulatory changes following RFA in the absence of any other therapeutic modalities. View Full-Text
Keywords: colorectal cancer; immunomodulation colorectal cancer; immunomodulation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Janikashvili, N.; Jayant, K.; Kikodze, N.; Mazmishvili, K.; Pantsulaia, I.; Sandhu, B.; Podda, M.; Iobadze, M.; Azrumelashvili, T.; Mizandari, M.; Habib, N.; Chikovani, T. Immunomodulatory Changes Following Isolated RF Ablation in Colorectal Liver Metastases: A Case Report. Medicines 2019, 6, 56.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicines EISSN 2305-6320 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top