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Open AccessCase Report

Massive Axial and Appendicular Skeletal Deformities in Connection with Gorham-Stout Syndrome

1
Ludwig Boltzmann Institute of Osteology, at the Hanusch Hospital of WGKK and, AUVA Trauma Centre Meidling, First Medical Department, Hanusch Hospital, 1140 Vienna, Austria
2
Orthopaedic Hospital of Speising, Paediatric Department, 1130 Vienna, Austria
3
Paediatric Orthopedic Surgery—Children Hospital, Tunis 1029, Tunis-Tunisia
4
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan
5
Department of Foot and Ankle Surgery, Neuroorthopaedics and Systemic Disorders, Pediatric Orthopedic Institute n.a. H. Turner, Parkovaya str., 64-68, 196603 Pushkin, Saint Petersburg, Russia
6
Department of Medical Chemistry, Medical University of Vienna, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Medicines 2019, 6(2), 54; https://doi.org/10.3390/medicines6020054
Received: 26 March 2019 / Revised: 30 April 2019 / Accepted: 5 May 2019 / Published: 7 May 2019
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Abstract

Background: Etiological understanding is the corner stone in the management of skeletal deformities. Methods: Multi-centre study of patients with deformities in connection with diverse etiological backgrounds. We aimed to study four patients (one boy and three girls) with variable axial and appendicular deformities in connection with a vanishing bone disorder. Results: Axial deformities such as scoliosis, kyphoscoliosis, compressed fused vertebrae, appendicular fractures, dislocations, and vicious disorganization deformities of the joints were in connection with the vanishing bone disorder, namely Gorham-Stout syndrome. Conclusions: It is mandatory to establish proper clinical and radiological phenotypic characterization in children and adults presented with unusual skeletal deformities. Identifying the reason behind these deformities is the key factor to draw a comprehensive management plan. View Full-Text
Keywords: spine deformities; joints and long bone deformities; vanishing bone disorder; gorham-stout disease; CT scan spine deformities; joints and long bone deformities; vanishing bone disorder; gorham-stout disease; CT scan
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Al Kaissi, A.; Bouchoucha, S.; Shboul, M.; Kenis, V.; Grill, F.; Ganger, R.; Kircher, S.G. Massive Axial and Appendicular Skeletal Deformities in Connection with Gorham-Stout Syndrome. Medicines 2019, 6, 54.

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