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Medicines 2017, 4(4), 88;

Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies

Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
GUSTO A Research Group, Chittagong 4000, Bangladesh
Comilla Medical College, Faculty of Medicine, University of Chittagong, Chittagong 4331, Bangladesh
Department of Microbiology, Jagannath University, Dhaka 1100, Bangladesh
Author to whom correspondence should be addressed.
Academic Editors: Gerhard Litscher and William N. Setzer
Received: 1 November 2017 / Revised: 25 November 2017 / Accepted: 28 November 2017 / Published: 1 December 2017
(This article belongs to the Special Issue Bioactivities and Medical Use of Herbs and Plants)
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Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis. Methods: Antinociceptive activity was determined by acetic acid-induced writhing and formalin-induced licking test in mice. Then, molecular docking study was performed to identify compounds having maximum activity against the COX-1 enzyme using Schrödinger Maestro (version 10.1) to determine docking fitness. Results: A preliminary phytochemical analysis of Met.MD revealed that it contained alkaloids, carbohydrates, phenols, flavonoids, tannins, and terpenoids. Met.MD exhibited a dose-dependent and statistically significant antinociceptive activity in the acetic acid and formalin test at the doses of 200 and 400 mg/kg. In addition, our docking study showed that macarangin had the best fitness score of −5.81 with COX-1 enzyme among six major compounds of M. denticulata. Conclusions: Results of the present study confirmed the potential antinociceptive activity of M. denticulata leaf extract in both in vivo and in silico models. View Full-Text
Keywords: Macaranga denticulata; COX-1; molecular docking; antinociceptive activity Macaranga denticulata; COX-1; molecular docking; antinociceptive activity

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Hasanat, A.; Chowdhury, T.A.; Kabir, M.S.H.; Chowdhury, M.S.; Chy, M.N.U.; Barua, J.; Chakrabarty, N.; Paul, A. Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies. Medicines 2017, 4, 88.

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