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Therapeutic Effect of Polidocanol Sclerotherapy on Oral Vascular Malformations

Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan
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Academic Editor: Gabriele Cervino
Dent. J. 2021, 9(10), 119; https://doi.org/10.3390/dj9100119
Received: 14 September 2021 / Revised: 1 October 2021 / Accepted: 8 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Oral Cancer: Diagnosis and Treatment II)
Various treatments for oral vascular malformation (VM) have been reported. Polidocanol and absolute ethanol have also been reported for sclerotherapy. However, there are still few reports on the therapeutic effect and dosage of polidocanol sclerotherapy. Therefore, we examined its therapeutic effects on oral VM. There were 17 sites of VMs, with nine patients diagnosed with oral VM at the Department of Dental and Oral Surgery, Tsukuba University Hospital. The medical records were retrospectively investigated to determine the site, hemangioma volume, polidocanol injection volume, and therapeutic effect. The volume of hemangiomas was calculated using magnetic resonance images. Based on the site, oral VMs were observed in the tongue, buccal mucosa, lips, and oral floor in eight, three, five, and one patients, respectively. The average size of the site was 3071 mm3. The average injection dose of polidocanol at one site was 2.86 mL, the average number of administrations was 1.6, and the response rate was 88.2%. No adverse events were observed. The median numerical rating scale scores were 2/10 (0–6/10) and 0/10 (0–1/10) the day after surgery and 1 week after surgery, respectively. Univariate regression analysis of the total dose in successful cases provided the following formula: 1.3 + 0.00025 × volume (mm3) (mg). Polidocanol sclerotherapy is an effective treatment method for oral VM. View Full-Text
Keywords: oral vascular malformation (VM); polidocanol; sclerotherapy oral vascular malformation (VM); polidocanol; sclerotherapy
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MDPI and ACS Style

Fukuzawa, S.; Yamagata, K.; Okubo-Sato, M.; Terada, K.; Uchida, F.; Ishibashi-Kanno, N.; Bukawa, H. Therapeutic Effect of Polidocanol Sclerotherapy on Oral Vascular Malformations. Dent. J. 2021, 9, 119. https://doi.org/10.3390/dj9100119

AMA Style

Fukuzawa S, Yamagata K, Okubo-Sato M, Terada K, Uchida F, Ishibashi-Kanno N, Bukawa H. Therapeutic Effect of Polidocanol Sclerotherapy on Oral Vascular Malformations. Dentistry Journal. 2021; 9(10):119. https://doi.org/10.3390/dj9100119

Chicago/Turabian Style

Fukuzawa, Satoshi, Kenji Yamagata, Makiko Okubo-Sato, Kazuhiro Terada, Fumihiko Uchida, Naomi Ishibashi-Kanno, and Hiroki Bukawa. 2021. "Therapeutic Effect of Polidocanol Sclerotherapy on Oral Vascular Malformations" Dentistry Journal 9, no. 10: 119. https://doi.org/10.3390/dj9100119

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