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Microbiological and Clinical Aspects of Cervicofacial Actinomyces Infections: An Overview

Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Eötvös utca 6., Hungary
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6725 Szeged, Semmelweis utca 6., Hungary
Department of Public Health, Faculty of Medicine, University of Szeged, 6720 Szeged, Dóm tér 10., Hungary
Author to whom correspondence should be addressed.
Dent. J. 2019, 7(3), 85;
Received: 30 July 2019 / Revised: 20 August 2019 / Accepted: 23 August 2019 / Published: 1 September 2019
Similarly to other non-spore-forming Gram-positive anaerobes, members of the Actinomyces genus are important saprophytic constituents of the normal microbiota of humans. Actinomyces infections are considered to be rare, with cervicofacial infections (also known as ‘lumpy jaw syndrome’) being the most prevalent type in the clinical practice. Actinomycoses are characterized by a slowly progressing (indolent) infection, with non-specific symptoms, and additionally, the clinical presentation of the signs/symptoms can mimic other pathologies, such as solid tumors, active Mycobacterium tuberculosis infections, nocardiosis, fungal infections, infarctions, and so on. The clinical diagnosis of actinomycosis may be difficult due to its non-specific symptoms and the fastidious, slow-growing nature of the pathogens, requiring an anaerobic atmosphere for primary isolation. Based on 111 references, the aim of this review is to summarize current advances regarding the clinical features, diagnostics, and therapy of cervicofacial Actinomyces infections and act as a paper for dentistry specialists, other physicians, and clinical microbiologists. View Full-Text
Keywords: Actinomyces; actinomycosis; cervicofacial infection Actinomyces; actinomycosis; cervicofacial infection
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Gajdács, M.; Urbán, E.; Terhes, G. Microbiological and Clinical Aspects of Cervicofacial Actinomyces Infections: An Overview. Dent. J. 2019, 7, 85.

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