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Effect of Violet-Blue Light on Streptococcus mutans-Induced Enamel Demineralization

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Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN 46202, USA
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Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, IN 46202, USA
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Department of Operative Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
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Department of Biostatistics, Indiana University, Indianapolis, IN 46202, USA
*
Authors to whom correspondence should be addressed.
Dent. J. 2018, 6(2), 6; https://doi.org/10.3390/dj6020006
Received: 18 February 2018 / Revised: 15 March 2018 / Accepted: 16 March 2018 / Published: 21 March 2018
Background: This in vitro study determined the effectiveness of violet-blue light (405 nm) on inhibiting Streptococcus mutans-induced enamel demineralization. Materials and Methods: S. mutans UA159 biofilm was grown on human enamel specimens for 13 h in 5% CO2 at 37 °C with/without 1% sucrose. Wet biofilm was treated twice daily with violet-blue light for five minutes over five days. A six-hour reincubation was included daily between treatments excluding the final day. Biofilms were harvested and colony forming units (CFU) were quantitated. Lesion depth (L) and mineral loss (∆Z) were quantified using transverse microradiography (TMR). Quantitative light-induced fluorescence Biluminator (QLF-D) was used to determine mean fluorescence loss. Data were analyzed using one-way analysis of variance (ANOVA) to compare differences in means. Results: The results demonstrated a significant reduction in CFUs between treated and non-treated groups grown with/without 1% sucrose. ∆Z was significantly reduced for specimens exposed to biofilms grown without sucrose with violet-blue light. There was only a trend on reduction of ∆Z with sucrose and with L on both groups. There were no differences in fluorescence-derived parameters between the groups. Conclusions: Within the limitations of the study, the results indicate that violet-blue light can serve as an adjunct prophylactic treatment for reducing S. mutans biofilm formation and enamel mineral loss. View Full-Text
Keywords: violet-blue light; phototherapy; Streptococcus mutans; dental caries violet-blue light; phototherapy; Streptococcus mutans; dental caries
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Felix Gomez, G.G.; Lippert, F.; Ando, M.; Zandona, A.F.; Eckert, G.J.; Gregory, R.L. Effect of Violet-Blue Light on Streptococcus mutans-Induced Enamel Demineralization. Dent. J. 2018, 6, 6.

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