Next Article in Journal
Environmental Factors Influencing Adoption of Canadian Guidelines on Smoking Cessation in Dental Healthcare Settings in Quebec: A Qualitative Study of Dentists’ Perspectives
Next Article in Special Issue
Role of Teriparatide in Medication-Related Osteonecrosis of the Jaws (MRONJ)
Previous Article in Journal / Special Issue
Current Controversies on the Pathogenesis of Medication-Related Osteonecrosis of the Jaw
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Dentistry Journal
Volume 4
Issue 4
10.3390/dj4040039
dentistry-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement thumb_up
...
textsms
...
Open AccessCase Report

Delayed Diagnosis of Osteonecrosis of the Jaw (ONJ) Associated with Bevacizumab Therapy in Colorectal Cancer Patients: Report of Two Cases

by
Francesco Erovigni
1,*,
Alessio Gambino
1,*,
Marco Cabras
1,
Antonella Fasciolo
2,
Silvio Diego Bianchi
3,
Elisa Bellini
4 and
Vittorio Fusco
5,6,*
1
Oral Surgery Department, Dental School, AOUP Città della Salute e della Scienza di Torino, Torino 10100, Italy
2
Maxillofacial Unit, Alessandria Hospital, Alessandria 15121, Italy
3
Radiology Department, Dental School, AOUP Città della Salute e della Scienza di Torino, Torino 10100, Italy
4
Oncology Unit, Molinette Hospital, AOUP Città della Salute e della Scienza di Torino, Torino 10100, Italy
5
Oncology Unit, Alessandria Hospital, Alessandria 15121, Italy
6
Centro di Documentazione Osteonecrosi, Alessandria 15121, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Christian Walter
Dent. J. 2016, 4(4), 39; https://doi.org/10.3390/dj4040039
Received: 7 September 2016 / Revised: 22 October 2016 / Accepted: 24 October 2016 / Published: 29 October 2016
(This article belongs to the Special Issue New Cancer and Osteoporosis Therapies and Osteocrosis of the Jaws)
View Full-Text Download PDF
Browse Figures
Cite This Paper

Abstract

Medication-induced Osteonecrosis of the Jaw (MRONJ) has been reported not only after use of antiresorptive agents (bisphosphonates and denosumab), but also in cancer patients receiving antiangiogenic agents, alone or combined with antiresorptive drugs. We report two cases of MRONJ observed in colorectal cancer patients after bevacizumab therapy only. MRONJ was diagnosed, respectively, two and seven months after a tooth extraction; both the patients had received two courses of bevacizumab infusions (for a total of 29 and 10 administrations, respectively). We discuss if tooth extraction during or after antiangiogenic therapy could be a potential trigger of MRONJ, but also if an underlying bone disease not evident before oral surgery might be a possible cause. A careful drug history has to be registered by dental specialists in cancer patients before oral surgery and adequate imaging might be obtained to avoid a delayed diagnosis. View Full-Text
Keywords: colorectal cancer; bevacizumab; osteonecrosis of jaw; ONJ; MRONJ; bisphosphonate colorectal cancer; bevacizumab; osteonecrosis of jaw; ONJ; MRONJ; bisphosphonate
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
SciFeed

Share and Cite

MDPI and ACS Style

Erovigni, F.; Gambino, A.; Cabras, M.; Fasciolo, A.; Bianchi, S.D.; Bellini, E.; Fusco, V. Delayed Diagnosis of Osteonecrosis of the Jaw (ONJ) Associated with Bevacizumab Therapy in Colorectal Cancer Patients: Report of Two Cases. Dent. J. 2016, 4, 39.

AMA Style

Erovigni F, Gambino A, Cabras M, Fasciolo A, Bianchi SD, Bellini E, Fusco V. Delayed Diagnosis of Osteonecrosis of the Jaw (ONJ) Associated with Bevacizumab Therapy in Colorectal Cancer Patients: Report of Two Cases. Dentistry Journal. 2016; 4(4):39.

Chicago/Turabian Style

Erovigni, Francesco; Gambino, Alessio; Cabras, Marco; Fasciolo, Antonella; Bianchi, Silvio D.; Bellini, Elisa; Fusco, Vittorio. 2016. "Delayed Diagnosis of Osteonecrosis of the Jaw (ONJ) Associated with Bevacizumab Therapy in Colorectal Cancer Patients: Report of Two Cases" Dent. J. 4, no. 4: 39.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop