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Article

A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases

by
Yasir Ramzan
1,
Hanadi Alzubadi
2,
Aziz Ullah Awan
1,*,
Kamel Guedri
3,
Mohammed Alharthi
4 and
Bandar M. Fadhl
3,5
1
Department of Mathematics, University of the Punjab, Lahore 54590, Pakistan
2
Department of Mathematics, Umm Al-Qura University, Makkah 24382, Saudi Arabia
3
Mechanical Engineering Department, College of Engineering and Architecture, Umm Al-Qura University, Makkah 21955, Saudi Arabia
4
Department of Mathematics, College of Sciences, University of Bisha, P.O. Box 344, Bisha 61922, Saudi Arabia
5
King Salman Center for Disability Research, Riyadh 11614, Saudi Arabia
*
Author to whom correspondence should be addressed.
Math. Comput. Appl. 2024, 29(6), 102; https://doi.org/10.3390/mca29060102
Submission received: 22 October 2024 / Accepted: 4 November 2024 / Published: 7 November 2024
(This article belongs to the Special Issue New Trends in Biomathematics)
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Abstract

This study aims to analyze the dynamics of Lassa fever transmission and its impact on the brain and spinal cord then devise and analyze preventive actions. The stability of the infection-free equilibrium point is evaluated; the model’s precision is examined using empirical data; and all parameters are estimated and fitted. Subsequently, the basic reproductive number is determined, and subpopulation trends are observed over time. Sensitivity analysis is conducted to identify critical drivers influencing transmission dynamics. Two-dimensional plots visualize the impact of crucial parameters on the reproductive number. Through a comprehensive literature review and case analysis, an association between Lassa fever and various disabilities is established, including conditions such as encephalitis, hearing loss, ataxia, neuropsychiatric manifestations, meningitis, seizures, and coma. Solutions are devised and analyzed to enhance early detection, treatment, and mitigation of disease.
Keywords: mathematical application; Lassa virus; disabilities; empirical data; sensitivity analysis; optimal control mathematical application; Lassa virus; disabilities; empirical data; sensitivity analysis; optimal control

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MDPI and ACS Style

Ramzan, Y.; Alzubadi, H.; Awan, A.U.; Guedri, K.; Alharthi, M.; Fadhl, B.M. A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases. Math. Comput. Appl. 2024, 29, 102. https://doi.org/10.3390/mca29060102

AMA Style

Ramzan Y, Alzubadi H, Awan AU, Guedri K, Alharthi M, Fadhl BM. A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases. Mathematical and Computational Applications. 2024; 29(6):102. https://doi.org/10.3390/mca29060102

Chicago/Turabian Style

Ramzan, Yasir, Hanadi Alzubadi, Aziz Ullah Awan, Kamel Guedri, Mohammed Alharthi, and Bandar M. Fadhl. 2024. "A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases" Mathematical and Computational Applications 29, no. 6: 102. https://doi.org/10.3390/mca29060102

APA Style

Ramzan, Y., Alzubadi, H., Awan, A. U., Guedri, K., Alharthi, M., & Fadhl, B. M. (2024). A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases. Mathematical and Computational Applications, 29(6), 102. https://doi.org/10.3390/mca29060102

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