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Mathematical and Computational Applications is published by MDPI from Volume 21 Issue 1 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Association for Scientific Research (ASR).
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Article

Two-Stage Group Sequential Designs for Comparative Clinical Trials

by
Sevil Bacanlı
1,*,
Özgür K. Peker
2 and
Yaprak Parlak Demirhan
1
1
Hacettepe University, Faculty of Science, Department of Statistics, 06800 Beytepe, Ankara, Turkey
2
Anadolu University, Faculty of Science, Department of Satistics, Eskişehir, Turkey
*
Author to whom correspondence should be addressed.
Math. Comput. Appl. 2008, 13(1), 31-40; https://doi.org/10.3390/mca13010031
Published: 1 April 2008
Versions Notes

Abstract

Group sequential designs are widely used in Phase II clinical trials, which are usually undertaken to evaluate the response probability of specific treatment regimen. In most randomized clinical trials with sequential patient entry, fixed sample size design is unjustified on ethical grounds and sequential designs are often impractical. However group sequential designs are generally more practical and they provide much of the saving possible from sequential designs. Optimal restricted two-stage design is the simplest form of a group sequential design.
In this study, group sequential design obtained by α*(t) functions characterized using the type-I error probability and optimal restricted two stage design has been compared for the cases that the group sizes are equal. Furthermore, their efficiency regarding fixed sample size design has been calculated and the results have been discussed.
Keywords: Group sequential design; Clinical trials; Two-stage design; Efficiency Group sequential design; Clinical trials; Two-stage design; Efficiency

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MDPI and ACS Style

Bacanlı, S.; Peker, Ö.K.; Demirhan, Y.P. Two-Stage Group Sequential Designs for Comparative Clinical Trials. Math. Comput. Appl. 2008, 13, 31-40. https://doi.org/10.3390/mca13010031

AMA Style

Bacanlı S, Peker ÖK, Demirhan YP. Two-Stage Group Sequential Designs for Comparative Clinical Trials. Mathematical and Computational Applications. 2008; 13(1):31-40. https://doi.org/10.3390/mca13010031

Chicago/Turabian Style

Bacanlı, Sevil, Özgür K. Peker, and Yaprak Parlak Demirhan. 2008. "Two-Stage Group Sequential Designs for Comparative Clinical Trials" Mathematical and Computational Applications 13, no. 1: 31-40. https://doi.org/10.3390/mca13010031

APA Style

Bacanlı, S., Peker, Ö. K., & Demirhan, Y. P. (2008). Two-Stage Group Sequential Designs for Comparative Clinical Trials. Mathematical and Computational Applications, 13(1), 31-40. https://doi.org/10.3390/mca13010031

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