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Separations 2016, 3(2), 12;

Exploring Gradients in Electrophoretic Separation and Preconcentration on Miniaturized Devices

School of Molecular Sciences, Arizona State University, Tempe, AZ 85274, USA
Author to whom correspondence should be addressed.
Academic Editor: Timothy Strein
Received: 14 December 2015 / Revised: 22 February 2016 / Accepted: 2 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Electrophoretic Analyses in Capillaries and Microfluidic Devices)
Full-Text   |   PDF [2935 KB, uploaded 1 April 2016]   |  


Over the last two decades, miniaturization, integration, and automation have made microfluidic systems popular. Core to advances in microfluidics are numerous electrophoretic separation and preconcentration strategies, some finding their origins on bench-top systems. Among them, gradient-based strategies are especially effective in addressing sensitivity challenges. This review introduces several gradient-based techniques according to a broad definition, including conductivity, field, and concentration, organized by the method of gradient generation. Each technique is introduced and described, and recent seminal advances explored. View Full-Text
Keywords: gradient; microdevice; electrophoretic separation; preconcentration gradient; microdevice; electrophoretic separation; preconcentration

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Zhu, F.; Hayes, M.A. Exploring Gradients in Electrophoretic Separation and Preconcentration on Miniaturized Devices. Separations 2016, 3, 12.

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