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10.11599/germs.2012.1018
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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

The Winding Road to Developing a Malaria Vaccine: Study Hypothesis

by
Hilary Denis Solomons
1,*,
Chris Gerhardus Joubert
2,
Bonnie Beichter
3 and
Zelda Haefele
4
1
M Med Hematology, Pathology, University of the Witwatersrand, P.O. Box 64203, Highlands North 2037, South Africa
2
Meiring and Partners, Pathology, Benoni, South Africa
3
Meiring and Partners, Pharmacy, Benoni, South Africa
4
University of Johannesburg, Johannesburg, South Africa
*
Author to whom correspondence should be addressed.
GERMS 2012, 2(3), 91-94; https://doi.org/10.11599/germs.2012.1018
Submission received: 22 June 2012 / Revised: 22 July 2012 / Accepted: 19 August 2012 / Published: 1 September 2012
Versions Notes

Abstract

In Africa, a child dies every 30 seconds from malaria, a vector-borne parasitic disease caused by Plasmodium spp, with higher mortality and severe forms of disease more frequently associated with Plasmodium falciparum infection. By looking at the natural resistance to malaria conferred by sickle cell trait, we hypothesize that a malaria therapeutical vaccine targeting the erythrocyte stage of the parasite through erythrocyte sickling could reduce parasite density and control the progression and severity of disease, thus decreasing the morbidity and mortality associated with severe forms of malaria.
Keywords: malaria; falciparum; infection; sickle cell; vaccine malaria; falciparum; infection; sickle cell; vaccine

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MDPI and ACS Style

Solomons, H.D.; Joubert, C.G.; Beichter, B.; Haefele, Z. The Winding Road to Developing a Malaria Vaccine: Study Hypothesis. GERMS 2012, 2, 91-94. https://doi.org/10.11599/germs.2012.1018

AMA Style

Solomons HD, Joubert CG, Beichter B, Haefele Z. The Winding Road to Developing a Malaria Vaccine: Study Hypothesis. GERMS. 2012; 2(3):91-94. https://doi.org/10.11599/germs.2012.1018

Chicago/Turabian Style

Solomons, Hilary Denis, Chris Gerhardus Joubert, Bonnie Beichter, and Zelda Haefele. 2012. "The Winding Road to Developing a Malaria Vaccine: Study Hypothesis" GERMS 2, no. 3: 91-94. https://doi.org/10.11599/germs.2012.1018

APA Style

Solomons, H. D., Joubert, C. G., Beichter, B., & Haefele, Z. (2012). The Winding Road to Developing a Malaria Vaccine: Study Hypothesis. GERMS, 2(3), 91-94. https://doi.org/10.11599/germs.2012.1018

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