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Volume 2
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10.11599/germs.2012.1008
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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

Serum Adipokines and HIV Viral Replication in Patients Undergoing Antiretroviral Therapy

by
Victoria Aramă
1,2,
Cătălin Tilişcan
2,3,*,
Daniela Adriana Ion
4,
Raluca Mihăilescu
2,
Daniela Munteanu
2,
Anca Streinu-Cercel
1,2,
Ana Maria Tudor
1,2,
Adriana Hristea
1,2,
Viorica Leoveanu
2,
Ioana Olaru
2 and
Ştefan Sorin Aramă
3
1
Department of Infectious Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2
National Institute for Infectious Diseases ‘Prof. Dr. Matei Balş’, 1 Dr. Calistrat Grozovici Street, Bucharest, Romania
3
Department of Physiopathology and Immunology, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020022 Bucharest, Romania
4
Department of Physiopathology II, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
*
Author to whom correspondence should be addressed.
GERMS 2012, 2(1), 12-17; https://doi.org/10.11599/germs.2012.1008
Submission received: 1 December 2011 / Revised: 1 January 2012 / Accepted: 1 February 2012 / Published: 1 March 2012
Versions Notes

Abstract

Introduction: Several studies have reported that cytokines secreted by adipose tissue (adipokines) may be linked to HIV replication. The aim of the study was to evaluate the relationship between HIV replication and serum levels of adipokines, in a Caucasian HIV-infected population of men and women undergoing complex antiretroviral therapy. Methods: A cross-sectional study was conducted in an unselected sample of 77 HIV-1-positive patients. Serum adipokines levels were measured including circulating adiponectin, leptin, resistin, tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). Patients were divided into two groups: Group 1—with undetectable viral load and Group 2—with persistent HIV viral replication. Differences between groups were tested using independent-sample t-test for Gaussian variables and Mann–Whitney–Wilcoxon test for non-parametric variables. Pearson's chi-squared test was used for correlation analysis. Results: A total of 77 patients (age range: 17–65, mean: 32.5 years) including 44 men (57.1% men, age range: 17–63 years, mean: 34.1 years) and 33 women (42.9% women age range: 19–65 years, mean: 30.3 years) were included in the study. TNF-alpha had significantly higher serum levels in patients with detectable viral load (16.89 vs. 9.35 pg/mL), (p = 0.043), but correlation analysis lacked statistical significance. Adiponectin had median serum levels of 9.22 μg/mL in Group 1 vs. 16.50 μg/mL in Group 2 but the results lacked statistical significance (p = 0.059). Higher leptin, IL-6 and resistin serum levels were noted in patients with undetectable HIV viral load, without statistical significance. Conclusions: The present study reported higher TNF-alpha serum levels in patients with persistent HIV viral load. We found no statistically significant correlations between adiponectin, leptin, resistin and IL-6 and HIV viral load in our Caucasian HIV-positive study population, undergoing antiretroviral therapy.
Keywords: adipokines; adiponectin; leptin; resistin; TNF-alpha; HIV adipokines; adiponectin; leptin; resistin; TNF-alpha; HIV

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MDPI and ACS Style

Aramă, V.; Tilişcan, C.; Ion, D.A.; Mihăilescu, R.; Munteanu, D.; Streinu-Cercel, A.; Tudor, A.M.; Hristea, A.; Leoveanu, V.; Olaru, I.; et al. Serum Adipokines and HIV Viral Replication in Patients Undergoing Antiretroviral Therapy. GERMS 2012, 2, 12-17. https://doi.org/10.11599/germs.2012.1008

AMA Style

Aramă V, Tilişcan C, Ion DA, Mihăilescu R, Munteanu D, Streinu-Cercel A, Tudor AM, Hristea A, Leoveanu V, Olaru I, et al. Serum Adipokines and HIV Viral Replication in Patients Undergoing Antiretroviral Therapy. GERMS. 2012; 2(1):12-17. https://doi.org/10.11599/germs.2012.1008

Chicago/Turabian Style

Aramă, Victoria, Cătălin Tilişcan, Daniela Adriana Ion, Raluca Mihăilescu, Daniela Munteanu, Anca Streinu-Cercel, Ana Maria Tudor, Adriana Hristea, Viorica Leoveanu, Ioana Olaru, and et al. 2012. "Serum Adipokines and HIV Viral Replication in Patients Undergoing Antiretroviral Therapy" GERMS 2, no. 1: 12-17. https://doi.org/10.11599/germs.2012.1008

APA Style

Aramă, V., Tilişcan, C., Ion, D. A., Mihăilescu, R., Munteanu, D., Streinu-Cercel, A., Tudor, A. M., Hristea, A., Leoveanu, V., Olaru, I., & Aramă, Ş. S. (2012). Serum Adipokines and HIV Viral Replication in Patients Undergoing Antiretroviral Therapy. GERMS, 2(1), 12-17. https://doi.org/10.11599/germs.2012.1008

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