Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis
Abstract
Introduction
Methods
Search plan
Eligibility criteria
Quality assessment
Data extraction
Data analysis
Results
Prevalence of total ica operon genes in S. aureus
Total biofilm formation rate in S. aureus strains
Correlation between the prevalence of these genes with biofilm formation and antibiotic resistance
Heterogeneity analysis and publication bias among the studies included
Sensitivity analyses
Discussion
Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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| Study | Year of study | Publication | Location | Samples | S. aureus isolates | Biofilm total (n) | MSSA biofilm (n) | MRSA biofilm (n) | Methods for biofilm | Molecular methods | ica genes n/% | icaA gene | icaB gene | icaA/D | icaD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Šmitran et al. [12] | 2019- 2020 | 2022 | Bosnia and Herzegovina | 363 | 60 | 53 | 29 | 24 | MTP | PCR | 30 | - | - | - | - |
| Shafi et al. [13] | 2019- 2020 | 2022 | Egypt | 66 | 46 | 46 | - | - | MTP | PCR | - | 9 | 10 | - | - |
| Manandhar et al. [14] | 2017- 2018 | 2021 | Nepal | 375 | 161 | 84 | 14 | 70 | TCP | PCR | 45 | - | - | - | - |
| Shivaee et al. [15] | - | 2019 | Iran | - | 100 | 100 | 50 | 50 | MTP | Real-time PCR | - | - | - | - | - |
| Babra et al. [16] | - | 2013 | Australia | - | 31 | 31 | - | - | CRA/TCP | PCR | - | - | -- | 23 | - |
| El-Mahallawy et al. [17] | - | 2009 | Egypt | - | 10 | 6 | - | - | CRA | - | - | 5 | - | - | - |
| Jasińska et al. [6] | 2021 | Poland | - | 26 | 7 | 5 | 2 | MTP | PCR | 11 | - | - | 1 | 10 | |
| dos Santos- Goes et al. [18] | 2017 | 2021 | Brazil | 63 | 59 | 59 | - | - | CRA | PCR | - | 38 | - | 35 | 54 |
| Azmi et al. [19] | 2015- 2018 | 2019 | Palestinian | - | 248 | 248 | - | 248 | MTP | PCR | - | 41 | - | 248 | 207 |
| Bimanand et al. [20] | 2012- 2013 | 2018 | Iran | - | 96 | 92 | - | 92 | MTP | PCR | - | 15 | 66 | - | 66 |
| Piechota et al. [21] | 2015- 2017 | 2018 | Poland | 130 | 129 | 57 | 72 | MTP | PCR | 67 | 4 | - | 20 | - | |
| Mollaahmadi et al. [22] | - | 2021 | Iran | 80 | 39 | 39 | - | 39 | CRA | PCR | - | 25 | 25 | - | 25 |
| Yousefi Nojookambari et al. [8] | 2015- 2016 | 2018 | Iran | - | 85 | 85 | - | 45 | CRA/TCP | PCR | - | 45 | - | - | 45 |
| Oufrid et al. [23] | - | 2015 | Morocco | - | 20 | 18 | - | - | MTP | PCR | - | 16 | - | - | 11 |
| Manandhar et al. [24] | - | 2018 | Nepal | - | 161 | 161 | 30 | 131 | CRA, TM, and TCP | PCR | - | - | - | 45 | - |
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Bamneshin, K.; Poudineh, M.; Alibabaei, R.H.; Amiri, M.R.J.; Fateminasab, Z.S.; Ghorbani, Z.; Maleki, R.; Khaledi, A. Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis. GERMS 2024, 14, 387-401. https://doi.org/10.18683/germs.2024.1448
Bamneshin K, Poudineh M, Alibabaei RH, Amiri MRJ, Fateminasab ZS, Ghorbani Z, Maleki R, Khaledi A. Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis. GERMS. 2024; 14(4):387-401. https://doi.org/10.18683/germs.2024.1448
Chicago/Turabian StyleBamneshin, Khadijeh, Mohsen Poudineh, Roya Haji Alibabaei, Mohammad Reza Jabbari Amiri, Zahra Sadat Fateminasab, Zahra Ghorbani, Reyhaneh Maleki, and Azad Khaledi. 2024. "Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis" GERMS 14, no. 4: 387-401. https://doi.org/10.18683/germs.2024.1448
APA StyleBamneshin, K., Poudineh, M., Alibabaei, R. H., Amiri, M. R. J., Fateminasab, Z. S., Ghorbani, Z., Maleki, R., & Khaledi, A. (2024). Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis. GERMS, 14(4), 387-401. https://doi.org/10.18683/germs.2024.1448



