Next Article in Journal
Attitudes and Acceptance of COVID-19 Vaccination Among Serbian Medical Students
Previous Article in Journal
Comparison of Microbial Preservation Methods: A Narrative Review
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
GERMS
Volume 14
Issue 4
10.18683/germs.2024.1448
germs-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis

by
Khadijeh Bamneshin
1,
Mohsen Poudineh
2,
Roya Haji Alibabaei
2,
Mohammad Reza Jabbari Amiri
3,
Zahra Sadat Fateminasab
2,
Zahra Ghorbani
,
Reyhaneh Maleki
2 and
Azad Khaledi
2,*
1
Department of Medical Physics, School of Medicine, Iranshahr University of Medical Sciences, 46 Imam Khomeini Street, Khomeini Corner, Iranshahr 9916643535, Iran
2
Infectious Diseases Research Center, Kashan University of Medical Sciences, 5th of Qotb–e Ravandi Blvd., Kashan 87154, Iran
3
Invasive Fungi Research Center, Department of Medical Mycology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 19395-4763, Iran
*
Author to whom correspondence should be addressed.
GERMS 2024, 14(4), 387-401; https://doi.org/10.18683/germs.2024.1448
Submission received: 19 June 2024 / Revised: 29 December 2024 / Accepted: 30 December 2024 / Published: 31 December 2024
Versions Notes

Abstract

We evaluated the gene prevalence of the icaADBC operon, its correlation with biofilm formation and antibiotic resistance through a global meta-analysis. We searched for articles that reported the prevalence of icaADBC operon, biofilm, and antibiotic resistance in S. aureus from 2000 up to 1st March 2024. The search was done in scientific databases such as PubMed, Scopus, Google Scholar, EMBASE, and Web of Science. The MESH keywords were: icaADBC operon, biofilm, methicillin-resistant Staphylococcus aureus, antibiotic resistance. Comprehensive Meta-Analysis Software was used for data analysis. The estimation of the combined prevalence of each desired variable was performed by depicting a forest plot through the random-effects model with a 95% confidence interval. Data heterogeneity was estimated by Q and I2 indices, and p-value <0.05 was reflected as statistically significant heterogeneity. Fifteen articles were eligible for inclusion. The prevalence of ica operon genes varied between 28–51.5%. The prevalence of total ica operon genes in S. aureus was reported at 42.4% (95%CI: 29.4–56.5). Biofilm formation prevalence of S. aureus isolates in different studies was reported between 10-100%. The rate of total biofilm in S. aureus was 95.8%. The rate of total strong, moderate, and weak biofilm in S. aureus was reported at 35.4%, 35.3%, and 23.9%, respectively. Most reviewed studies reported a correlation between ica genes and biofilm. We found that many studies reported a correlation between the high prevalence of ica operon genes, phenotypic biofilm production, and antibiotic resistance. Also, regardless of whether the strains were MRSA or not, the high biofilm formation ability was reported at 95.8% by most studies.
Keywords: Staphylococcus aureus; biofilms; antibiotic resistance; methicillin-resistant Staphylococcus aureus Staphylococcus aureus; biofilms; antibiotic resistance; methicillin-resistant Staphylococcus aureus

Share and Cite

MDPI and ACS Style

Bamneshin, K.; Poudineh, M.; Alibabaei, R.H.; Amiri, M.R.J.; Fateminasab, Z.S.; Ghorbani, Z.; Maleki, R.; Khaledi, A. Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis. GERMS 2024, 14, 387-401. https://doi.org/10.18683/germs.2024.1448

AMA Style

Bamneshin K, Poudineh M, Alibabaei RH, Amiri MRJ, Fateminasab ZS, Ghorbani Z, Maleki R, Khaledi A. Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis. GERMS. 2024; 14(4):387-401. https://doi.org/10.18683/germs.2024.1448

Chicago/Turabian Style

Bamneshin, Khadijeh, Mohsen Poudineh, Roya Haji Alibabaei, Mohammad Reza Jabbari Amiri, Zahra Sadat Fateminasab, Zahra Ghorbani, Reyhaneh Maleki, and Azad Khaledi. 2024. "Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis" GERMS 14, no. 4: 387-401. https://doi.org/10.18683/germs.2024.1448

APA Style

Bamneshin, K., Poudineh, M., Alibabaei, R. H., Amiri, M. R. J., Fateminasab, Z. S., Ghorbani, Z., Maleki, R., & Khaledi, A. (2024). Prevalence of icaADBC Genes, and Correlation with Biofilms and Antibiotic Resistance in S. aureus: A Systematic Review and Meta-Analysis. GERMS, 14(4), 387-401. https://doi.org/10.18683/germs.2024.1448

Article Metrics

Back to TopTop