Next Article in Journal
Isolation of Shiga Toxin-Producing Escherichia coli O157 and Non-O157 from Retail Imported Frozen Beef Marketed in Saudi Arabia Using Immunomagnetic Separation and Multiplex PCR
Previous Article in Journal
The Infectious Disease Burden Among War Related Internally Displaced People in the Lviv Region of Ukraine
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
GERMS
Volume 14
Issue 4
10.18683/germs.2024.1444
germs-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Influence of Farnesol and Tyrosol on Candida spp. Virulence Traits

by
Cristina Nicoleta Ciurea
1,2,
Anca Delia Mare
1,*,
Mihai Mareş
3,
Felicia Toma
1,
Irina-Bianca Kosovski
4,
Anca Cighir
1 and
Adrian Man
2
1
Department of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, 540139 Târgu Mureș, Romania
2
Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, 540139 Târgu Mureș, Romania
3
Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, Ion Ionescu de la Brad University of Agricultural Sciences and Veterinary Medicine, 8 Mihail Sadoveanu Alley, 700489 Iași, Romania
4
Department of Physiopathology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, 540139 Târgu Mureș, Romania
*
Author to whom correspondence should be addressed.
GERMS 2024, 14(4), 344-351; https://doi.org/10.18683/germs.2024.1444
Submission received: 26 July 2024 / Revised: 28 December 2024 / Accepted: 29 December 2024 / Published: 31 December 2024
Versions Notes

Abstract

Introduction: Intercellular communication helps regulate the cell density and the virulence traits in yeasts and bacteria. The study aims to identify the effects of quorum sensing molecules (QSMs) like farnesol and tyrosol on Candida spp. virulence traits. Methods: The effects of farnesol and tyrosol were studied on the growth rate of Candida albicans, Candida parapsilosis, Candida krusei, Candida auris, and Candida guilliermondii at different time points, on a 48 hours incubation period. The growth rate was assessed spectrophotometrically. The biofilm formation abilities of Candida spp. were assessed by crystal violet staining technique. Moreover, the expression of C. albicans virulence genes (ALS3, HSP70, SAP2) was analyzed as a response to 100 μM farnesol and tyrosol, by RT-PCR. Results: Generally, farnesol was found to inhibit the growth rate and biofilm formation mostly in non-albicans species, while tyrosol exerted a non-consistent response on the different Candida species. The expression of ALS3 and HSP70 in C. albicans was upregulated by the QSMs. Conclusions: Both farnesol and tyrosol are involved in the regulation of Candida spp. virulence mechanisms, dependent on the used concentration and exposure time and in a species-dependent manner.
Keywords: farnesol; tyrosol; Candida; growth rate; biofilms; ALS3; HSP70; SAP2 farnesol; tyrosol; Candida; growth rate; biofilms; ALS3; HSP70; SAP2

Share and Cite

MDPI and ACS Style

Ciurea, C.N.; Mare, A.D.; Mareş, M.; Toma, F.; Kosovski, I.-B.; Cighir, A.; Man, A. The Influence of Farnesol and Tyrosol on Candida spp. Virulence Traits. GERMS 2024, 14, 344-351. https://doi.org/10.18683/germs.2024.1444

AMA Style

Ciurea CN, Mare AD, Mareş M, Toma F, Kosovski I-B, Cighir A, Man A. The Influence of Farnesol and Tyrosol on Candida spp. Virulence Traits. GERMS. 2024; 14(4):344-351. https://doi.org/10.18683/germs.2024.1444

Chicago/Turabian Style

Ciurea, Cristina Nicoleta, Anca Delia Mare, Mihai Mareş, Felicia Toma, Irina-Bianca Kosovski, Anca Cighir, and Adrian Man. 2024. "The Influence of Farnesol and Tyrosol on Candida spp. Virulence Traits" GERMS 14, no. 4: 344-351. https://doi.org/10.18683/germs.2024.1444

APA Style

Ciurea, C. N., Mare, A. D., Mareş, M., Toma, F., Kosovski, I.-B., Cighir, A., & Man, A. (2024). The Influence of Farnesol and Tyrosol on Candida spp. Virulence Traits. GERMS, 14(4), 344-351. https://doi.org/10.18683/germs.2024.1444

Article Metrics

Back to TopTop