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Volume 14
Issue 1
10.18683/germs.2024.1416
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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

Occurrence of Acute Otitis and Sinusitis in Patients Hospitalized for Influenza

by
Vlad Ștefan Pleșca
1,
Adrian Gabriel Marinescu
1,
Cătălina Voiosu
2,
Anca Cristina Drăgănescu
1,*,
Anca Streinu-Cercel
1,
Alexandra Vilaia
2,
Răzvan Hainăroșie
2,
Doina Anca Pleșca
2 and
Oana Săndulescu
1
1
Carol Davila University of Medicine and Pharmacy Bucharest, Romania and National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, No. 1 Dr. Calistrat Grozovici street, 021105 Bucharest, Romania
2
Carol Davila University of Medicine and Pharmacy Bucharest, No. 37 Dionisie Lupu street, Bucharest, Romania
*
Author to whom correspondence should be addressed.
GERMS 2024, 14(1), 38-44; https://doi.org/10.18683/germs.2024.1416
Submission received: 27 February 2024 / Revised: 27 March 2024 / Accepted: 31 March 2024 / Published: 31 March 2024
Versions Notes

Abstract

Introduction: Acute otitis and sinusitis are common complications in patients with influenza and are responsible for increased hospitalization rates. Methods: A five-year retrospective study (2018–2023) was conducted including all patients hospitalized for influenza (etiologic diagnosis by RT-PCR) to identify the incidence and characteristics of cases complicated with otitis and/or sinusitis. Cases associated with other viral co-infections were excluded from the analysis. Results: We identified a cumulative rate of 20.6% (324 cases) of acute otitis (AO) and acute sinusitis (AS) among patients with influenza. Of these, 62.3% had AO, 28.1% AS, and 9.6% concomitant AO and AS. Cases of AO were predominant in the pediatric population (97.0%), while cases of AS were more common in adults (56.1%). Influenza A viruses were identified in 67.2% of patients. The infection with influenza B viruses increased the risk of acute congestive otitis media 2.1-fold (p = 0.020), and influenza A viruses increased the risk of acute maxillary sinusitis 2.7-fold (p = 0.029). Late presentation to the hospital, with a median of 4 days from the onset of influenza symptoms, was identified as a factor in the occurrence of AO and AS. Conclusions: The risk of AO and AS is increased in patients with influenza, especially in the pediatric population and in late hospital presentations. These findings highlight the importance of proper monitoring and management of patients with influenza to prevent the development of complications, as well as the need to better understand the mechanisms whereby influenza viruses contribute to these secondary conditions.
Keywords: acute otitis; acute sinusitis; ENT; influenza acute otitis; acute sinusitis; ENT; influenza

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MDPI and ACS Style

Pleșca, V.Ș.; Marinescu, A.G.; Voiosu, C.; Drăgănescu, A.C.; Streinu-Cercel, A.; Vilaia, A.; Hainăroșie, R.; Pleșca, D.A.; Săndulescu, O. Occurrence of Acute Otitis and Sinusitis in Patients Hospitalized for Influenza. GERMS 2024, 14, 38-44. https://doi.org/10.18683/germs.2024.1416

AMA Style

Pleșca VȘ, Marinescu AG, Voiosu C, Drăgănescu AC, Streinu-Cercel A, Vilaia A, Hainăroșie R, Pleșca DA, Săndulescu O. Occurrence of Acute Otitis and Sinusitis in Patients Hospitalized for Influenza. GERMS. 2024; 14(1):38-44. https://doi.org/10.18683/germs.2024.1416

Chicago/Turabian Style

Pleșca, Vlad Ștefan, Adrian Gabriel Marinescu, Cătălina Voiosu, Anca Cristina Drăgănescu, Anca Streinu-Cercel, Alexandra Vilaia, Răzvan Hainăroșie, Doina Anca Pleșca, and Oana Săndulescu. 2024. "Occurrence of Acute Otitis and Sinusitis in Patients Hospitalized for Influenza" GERMS 14, no. 1: 38-44. https://doi.org/10.18683/germs.2024.1416

APA Style

Pleșca, V. Ș., Marinescu, A. G., Voiosu, C., Drăgănescu, A. C., Streinu-Cercel, A., Vilaia, A., Hainăroșie, R., Pleșca, D. A., & Săndulescu, O. (2024). Occurrence of Acute Otitis and Sinusitis in Patients Hospitalized for Influenza. GERMS, 14(1), 38-44. https://doi.org/10.18683/germs.2024.1416

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