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A Modified Expectation Maximization Approach for Process Data Rectification
Perspective

On Catalytic Kinetics of Enzymes

by 1,2,3,4,5
1
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
2
Institute of Drug Discovery and Development, Zhengzhou University, Zhengzhou 450001, China
3
Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, China
4
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou 450001, China
5
University of Chinese Academy of Sciences, Beijing 100049, China
Academic Editor: Sérgio Filipe Sousa
Processes 2021, 9(2), 271; https://doi.org/10.3390/pr9020271
Received: 24 November 2020 / Revised: 25 January 2021 / Accepted: 26 January 2021 / Published: 30 January 2021
(This article belongs to the Special Issue Modeling and Simulation of Enzymatic Catalysis Processes)
Classical enzyme kinetic theories are summarized and linked with modern discoveries here. The sequential catalytic events along time axis by enzyme are analyzed at the molecular level, and by using master equations, this writing tries to connect the microscopic molecular behavior of enzyme to kinetic data (like velocity and catalytic coefficient k) obtained in experiment: 1/k = t equals to the sum of the times taken by the constituent individual steps. The relationships between catalytic coefficient k, catalytic rate or velocity, the amount of time taken by each step and physical or biochemical conditions of the system are discussed, and the perspective and hypothetic equations proposed here regarding diffusion, conformational change, chemical conversion, product release steps and the whole catalytic cycle provide an interpretation of previous experimental observations and can be testified by future experiments. View Full-Text
Keywords: catalysis; kinetics; time; enzyme; macromolecule; biological macro-substrate; catalytic step; catalytic efficiency; catalytic coefficient catalysis; kinetics; time; enzyme; macromolecule; biological macro-substrate; catalytic step; catalytic efficiency; catalytic coefficient
MDPI and ACS Style

Dong, J. On Catalytic Kinetics of Enzymes. Processes 2021, 9, 271. https://doi.org/10.3390/pr9020271

AMA Style

Dong J. On Catalytic Kinetics of Enzymes. Processes. 2021; 9(2):271. https://doi.org/10.3390/pr9020271

Chicago/Turabian Style

Dong, Jianshu. 2021. "On Catalytic Kinetics of Enzymes" Processes 9, no. 2: 271. https://doi.org/10.3390/pr9020271

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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