Quantitative Determination of Vitamins A and E in Ointments Using Raman Spectroscopy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Apparatus
2.2. Chemicals
2.3. Sample Preparation
2.4. Modeling and Spectral Data Treatment
3. Results
3.1. Preparation of the Ointment Base
3.2. PLS Modeling
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ointment Base System | Petrolatum | Eucerin | |
---|---|---|---|
API | Vitamin A | Vitamin A | Vitamin E |
Concentration range (%) | 0.016–0.079 | 0.022–0.084 | 0.317–1.419 |
R2 | 0.980 | 0.990 | 0.988 |
RCV | 0.836 | 0.853 | 0.817 |
RSEPcal (%) | 4.96 | 3.83 | 3.71 |
RSEPval (%) | 5.91 | 5.69 | 4.38 |
Number of LV | 4 | 4 | 5 |
Determined content (%) | 0.046 ± 0.003 | 0.045 ± 0.002 | 0.78 ± 0.02 |
Recovery (%) | 104.3 | 102.8 | 98.8 |
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Mazurek, S.; Pichlak, K.; Szostak, R. Quantitative Determination of Vitamins A and E in Ointments Using Raman Spectroscopy. Processes 2021, 9, 8. https://doi.org/10.3390/pr9010008
Mazurek S, Pichlak K, Szostak R. Quantitative Determination of Vitamins A and E in Ointments Using Raman Spectroscopy. Processes. 2021; 9(1):8. https://doi.org/10.3390/pr9010008
Chicago/Turabian StyleMazurek, Sylwester, Kamil Pichlak, and Roman Szostak. 2021. "Quantitative Determination of Vitamins A and E in Ointments Using Raman Spectroscopy" Processes 9, no. 1: 8. https://doi.org/10.3390/pr9010008
APA StyleMazurek, S., Pichlak, K., & Szostak, R. (2021). Quantitative Determination of Vitamins A and E in Ointments Using Raman Spectroscopy. Processes, 9(1), 8. https://doi.org/10.3390/pr9010008