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Article

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

1
Department of Physics, Sathyabama Institute of Science and Technology, Chennai-600 119, Tamil Nadu, India
2
Nanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia
3
Department of General Surgery, Madras Medical College, Chennai-600003, India
4
Department of Mechanical Engineering, College of Engineering, King Khalid University, PO Box 394, Abha 61421, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Processes 2019, 7(11), 826; https://doi.org/10.3390/pr7110826
Received: 1 October 2019 / Revised: 29 October 2019 / Accepted: 30 October 2019 / Published: 7 November 2019
Infections after bone reconstructive surgery become an authentic therapeutic and economic issue when it comes to a modern health care system. In general; infected bone defects are regarded as contraindications for bone grafting. Since the pathogens develop a biofilm on the inner surface of the bone; local delivery of antibiotics becomes more important. The present work focuses on the synthesis of Mesoporous Hydroxyapatite (MPHAP) loaded with drug Vancomycin (Van) and to investigate its loading and leaching ability in phosphate buffer solution (PBS), to be used for post-operative infections. The effect of pore size on MPHAP was analyzed using different fatty acids as organic modifiers. The impacts of various fatty acids chain length on the morphology and pore size were studied. A simple impregnation technique with optimized conditions ensured a high antibiotic loading (up to 0.476 + 0.0135 mg/mL), with a complete in vitro release obtained within 50 h. View Full-Text
Keywords: Hydroxyapatite; Sol-Gel synthesis; fatty acid; Vancomycin; drug delivery Hydroxyapatite; Sol-Gel synthesis; fatty acid; Vancomycin; drug delivery
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MDPI and ACS Style

Lett, J.A.; Sagadevan, S.; Prabhakar, J.J.; Hamizi, N.A.; Badruddin, I.A.; Johan, M.R.; Marlinda, A.R.; Abdul Wahab, Y.; Yunus Khan, T.M.; Kamangar, S. Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes. Processes 2019, 7, 826. https://doi.org/10.3390/pr7110826

AMA Style

Lett JA, Sagadevan S, Prabhakar JJ, Hamizi NA, Badruddin IA, Johan MR, Marlinda AR, Abdul Wahab Y, Yunus Khan TM, Kamangar S. Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes. Processes. 2019; 7(11):826. https://doi.org/10.3390/pr7110826

Chicago/Turabian Style

Lett, Jayasingh A., Suresh Sagadevan, Joseph J. Prabhakar, Nor A. Hamizi, Irfan A. Badruddin, Mohd R. Johan, Ab R. Marlinda, Yasmin Abdul Wahab, Tatagar M. Yunus Khan, and Sarfaraz Kamangar. 2019. "Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes" Processes 7, no. 11: 826. https://doi.org/10.3390/pr7110826

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