Next Article in Journal
Modelling of a Naphtha Recovery Unit (NRU) with Implications for Process Optimization
Previous Article in Journal
Mechanism of Viscous Oil Fire Flooding Dehumidification Equipment and Structure Optimization
Article

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
*
Author to whom correspondence should be addressed.
Processes 2018, 6(7), 73; https://doi.org/10.3390/pr6070073
Received: 29 May 2018 / Revised: 7 June 2018 / Accepted: 19 June 2018 / Published: 21 June 2018
Traditionally used herbal medicines are deep in the consciousness of patients for the treatment of only minor diseases by self-medication. However, manufacturers of herbal medicinal products suffer from major problems such as increasing market pressure by e.g., the food supplement sector, increasing regulations, and costs of production. Moreover, due to more stringent regulation and approval processes, innovation is hardly observed, and the methods used in process development are outdated. Therefore, this study aims to provide an approach based on modern process engineering concepts and including predictive process modelling and simulation for the extraction of traditional herbal medicines as complex extracts. The commonly used solvent-based percolation is critically assessed and compared to the so-called pressurized hot water extraction (PHWE) as a new possible alternative to replace organic solvents. In the study a systematic process design for the extraction of hawthorn (Crataegus monogyna JACQ.) is shown. While for traditional percolation the solvent is optimized to a mixture of ethanol and water (70/30 v/v), the PHWE is run at a temperature of 90 °C. The extracts of various harvest batches are compared to a commercially available product based on a chromatographic fingerprint. For the first time, natural batch variability was successfully incorporated into the physico-chemical process modelling concept. An economic feasibility study reveals that the PHWE is the best choice not only from a technical point of view but also from economic aspects. View Full-Text
Keywords: pressurized hot water extraction; modelling; simulation; harvest; variety pressurized hot water extraction; modelling; simulation; harvest; variety
Show Figures

Figure 1

MDPI and ACS Style

Sixt, M.; Strube, J. Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.). Processes 2018, 6, 73. https://doi.org/10.3390/pr6070073

AMA Style

Sixt M, Strube J. Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.). Processes. 2018; 6(7):73. https://doi.org/10.3390/pr6070073

Chicago/Turabian Style

Sixt, Maximilian, and Jochen Strube. 2018. "Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)" Processes 6, no. 7: 73. https://doi.org/10.3390/pr6070073

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop