Next Article in Journal
A General Model for Estimating Emissions from Integrated Power Generation and Energy Storage. Case Study: Integration of Solar Photovoltaic Power and Wind Power with Batteries
Next Article in Special Issue
Ultrasonic-Assisted Extraction and Swarm Intelligence for Calculating Optimum Values of Obtaining Boric Acid from Tincal Mineral
Previous Article in Journal
Effect of Control Horizon in Model Predictive Control for Steam/Water Loop in Large-Scale Ships
Open AccessArticle

A Green Process for the Extraction and Purification of Hesperidin from Mexican Lime Peel (Citrus aurantifolia Swingle) that is Extendible to the Citrus Genus

1
Tecnología Alimentaria, Biotecnología Industrial, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Normalistas 800, C.P. 44270, Guadalajara, Jalisco, Mexico
2
Departamento de Ingeniería Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara. Blvd. Marcelino García Barragán #1421, esq. Calzada Olímpica. C.P. 44430, Guadalajara, Jalisco, Mexico
*
Authors to whom correspondence should be addressed.
Processes 2018, 6(12), 266; https://doi.org/10.3390/pr6120266
Received: 13 November 2018 / Revised: 30 November 2018 / Accepted: 11 December 2018 / Published: 15 December 2018
(This article belongs to the Special Issue Green Separation and Extraction Processes)
The processing of Mexican limes generates great amounts of peel as a by-product. Lime peel is mainly rich in the flavonoid hesperidin, whose bioactivity is oriented mainly to cardiovascular diseases and cancer. The purpose of this work was to develop a green process for the extraction and purification of hesperidin from Mexican lime peel. The extraction of hesperidin was investigated on a laboratory scale by varying the solvent composition and the solid-to-solvent ratio, and then scaling this process (volume: 20 L). Next, a purification process using adsorption resins was assessed: first through static tests to determine the adsorption efficiency with two resins (FPX66, EXA118), and then on a packed column with 80 mL of resin at 25 °C. Lab-scale extraction showed that the best conditions were a solid-to-solvent ratio of 0.33 g/mL and 60% ethanol. After using these conditions at pilot scale and concentrating the solution, the hesperidin content of the extract was 0.303 mg/mL. Through static tests, higher adsorption efficiencies were achieved with the EXA-118 resin and diluted extract (4:6 ratio with 10% dimethylsulfoxide, (DMSO)). Finally, the purification process on a packed column from the diluted extract (hesperidin concentration of 0.109 mg/mL) had a mean recovery efficiency of almost 90%. View Full-Text
Keywords: Citrus aurantifolia Swingle; hesperidin; citrus byproducts; adsorption Citrus aurantifolia Swingle; hesperidin; citrus byproducts; adsorption
Show Figures

Graphical abstract

MDPI and ACS Style

Padilla de la Rosa, J.D.; Ruiz-Palomino, P.; Arriola-Guevara, E.; García-Fajardo, J.; Sandoval, G.; Guatemala-Morales, G.M. A Green Process for the Extraction and Purification of Hesperidin from Mexican Lime Peel (Citrus aurantifolia Swingle) that is Extendible to the Citrus Genus. Processes 2018, 6, 266.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop