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Open AccessArticle

A Green Process for the Extraction and Purification of Hesperidin from Mexican Lime Peel (Citrus aurantifolia Swingle) that is Extendible to the Citrus Genus

Tecnología Alimentaria, Biotecnología Industrial, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Normalistas 800, C.P. 44270, Guadalajara, Jalisco, Mexico
Departamento de Ingeniería Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara. Blvd. Marcelino García Barragán #1421, esq. Calzada Olímpica. C.P. 44430, Guadalajara, Jalisco, Mexico
Authors to whom correspondence should be addressed.
Processes 2018, 6(12), 266;
Received: 13 November 2018 / Revised: 30 November 2018 / Accepted: 11 December 2018 / Published: 15 December 2018
(This article belongs to the Special Issue Green Separation and Extraction Processes)
The processing of Mexican limes generates great amounts of peel as a by-product. Lime peel is mainly rich in the flavonoid hesperidin, whose bioactivity is oriented mainly to cardiovascular diseases and cancer. The purpose of this work was to develop a green process for the extraction and purification of hesperidin from Mexican lime peel. The extraction of hesperidin was investigated on a laboratory scale by varying the solvent composition and the solid-to-solvent ratio, and then scaling this process (volume: 20 L). Next, a purification process using adsorption resins was assessed: first through static tests to determine the adsorption efficiency with two resins (FPX66, EXA118), and then on a packed column with 80 mL of resin at 25 °C. Lab-scale extraction showed that the best conditions were a solid-to-solvent ratio of 0.33 g/mL and 60% ethanol. After using these conditions at pilot scale and concentrating the solution, the hesperidin content of the extract was 0.303 mg/mL. Through static tests, higher adsorption efficiencies were achieved with the EXA-118 resin and diluted extract (4:6 ratio with 10% dimethylsulfoxide, (DMSO)). Finally, the purification process on a packed column from the diluted extract (hesperidin concentration of 0.109 mg/mL) had a mean recovery efficiency of almost 90%. View Full-Text
Keywords: Citrus aurantifolia Swingle; hesperidin; citrus byproducts; adsorption Citrus aurantifolia Swingle; hesperidin; citrus byproducts; adsorption
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MDPI and ACS Style

Padilla de la Rosa, J.D.; Ruiz-Palomino, P.; Arriola-Guevara, E.; García-Fajardo, J.; Sandoval, G.; Guatemala-Morales, G.M. A Green Process for the Extraction and Purification of Hesperidin from Mexican Lime Peel (Citrus aurantifolia Swingle) that is Extendible to the Citrus Genus. Processes 2018, 6, 266.

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