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Development of Molecularly Imprinted Polymers to Target Polyphenols Present in Plant Extracts

1
LSRE-Instituto Politécnico de Bragança, Quinta de Santa Apolónia, 5300 Bragança, Portugal
2
LSRE-Faculdade de Engenharia da Universidade do Porto, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
*
Author to whom correspondence should be addressed.
Processes 2017, 5(4), 72; https://doi.org/10.3390/pr5040072
Received: 29 September 2017 / Revised: 7 November 2017 / Accepted: 9 November 2017 / Published: 14 November 2017
(This article belongs to the Special Issue Water Soluble Polymers)
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Abstract

The development of molecularly imprinted polymers (MIPs) to target polyphenols present in vegetable extracts was here addressed. Polydatin was selected as a template polyphenol due to its relatively high size and amphiphilic character. Different MIPs were synthesized to explore preferential interactions between the functional monomers and the template molecule. The effect of solvent polarity on the molecular imprinting efficiency, namely owing to hydrophobic interactions, was also assessed. Precipitation and suspension polymerization were examined as a possible way to change MIPs morphology and performance. Solid phase extraction and batch/continuous sorption processes were used to evaluate the polyphenols uptake/release in individual/competitive assays. Among the prepared MIPs, a suspension polymerization synthesized material, with 4-vinylpyridine as the functional monomer and water/methanol as solvent, showed a superior performance. The underlying cause of such a significant outcome is the likely surface imprinting process caused by the amphiphilic properties of polydatin. The uptake and subsequent selective release of polyphenols present in natural extracts was successfully demonstrated, considering a red wine solution as a case study. However, hydrophilic/hydrophobic interactions are inevitable (especially with complex natural extracts) and the tuning of the polarity of the solvents is an important issue for the isolation of the different polyphenols. View Full-Text
Keywords: molecular imprinting; crosslinking polymerization; polyphenols; adsorbents; amphiphilic materials; vegetable extracts; continuous processes molecular imprinting; crosslinking polymerization; polyphenols; adsorbents; amphiphilic materials; vegetable extracts; continuous processes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Gomes, C.; Sadoyan, G.; Dias, R.C.S.; Costa, M.R.P.F.N. Development of Molecularly Imprinted Polymers to Target Polyphenols Present in Plant Extracts. Processes 2017, 5, 72.

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