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Processes 2014, 2(2), 466-493;

Microreactors for Gold Nanoparticles Synthesis: From Faraday to Flow

School of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast BT9 5AG, UK
Author to whom correspondence should be addressed.
Received: 15 January 2014 / Revised: 15 March 2014 / Accepted: 1 April 2014 / Published: 5 June 2014
PDF [2866 KB, uploaded 5 June 2014]


The seminal work of Michael Faraday in 1850s transmuted the “Alchemy of gold” into a fascinating scientific endeavor over the millennia, particularly in the past half century. Gold nanoparticles (GNPs) arguably hold the central position of nanosciences due to their intriguing size-and-shape dependent physicochemical properties, non-toxicity, and ease of functionalization and potential for wide range of applications. The core chemistry involved in the syntheses is essentially not very different from what Michael Faraday resorted to: transforming ions into metallic gold using mild reducing agents. However, the process of such reduction and outcome (shapes and sizes) are intricately dependent on basic operational parameters such as sequence of addition and efficiency of mixing of the reagents. Hence, irreproducibility in synthesis and maintaining batch-to-batch quality are major obstacles in this seemingly straightforward process, which poses challenges in scaling-up. Microreactors, by the virtue of excellent control over reagent mixing in space and time within narrow channel networks, opened a new horizon of possibilities to tackle such problems to produce GNPs in more reliable, reproducible and scalable ways. In this review, we will delineate the state-of-the-art of GNPs synthesis using microreactors and will discuss in length how such “flask-to-chip” paradigm shift may revolutionize the very concept of nanosyntheses. View Full-Text
Keywords: gold nanoparticles; microfluidics; core-shell; nanorods; scale-up gold nanoparticles; microfluidics; core-shell; nanorods; scale-up

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Rahman, M.T.; Rebrov, E.V. Microreactors for Gold Nanoparticles Synthesis: From Faraday to Flow. Processes 2014, 2, 466-493.

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