Design and Validation of a Cyclic Strain Bioreactor to Condition Spatially-Selective Scaffolds in Dual Strain Regimes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Bioreactor System
2.2. Mechanical Characterization
2.3. Cellular Characterization
Group | Location | Stretch Schedule |
---|---|---|
Control | TCP Petri Dish | No stretch |
Unstretched | Bioreactor | No stretch |
Stretched | Bioreactor | 5%, 0.5 Hz, 1 h daily, 14 days |
2.4. Statistical Analysis
3. Results
3.1. Mechanical Characterization
3.2. Cellular Characterization
3.3. Matrix Characterization
4. Discussion
5. Conclusions
Acknowledgments
Conflicts of Interest
References
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Goodhart, J.M.; Cooper, J.O.; Smith, R.A.; Williams, J.L.; Haggard, W.O.; Bumgardner, J.D. Design and Validation of a Cyclic Strain Bioreactor to Condition Spatially-Selective Scaffolds in Dual Strain Regimes. Processes 2014, 2, 345-360. https://doi.org/10.3390/pr2020345
Goodhart JM, Cooper JO, Smith RA, Williams JL, Haggard WO, Bumgardner JD. Design and Validation of a Cyclic Strain Bioreactor to Condition Spatially-Selective Scaffolds in Dual Strain Regimes. Processes. 2014; 2(2):345-360. https://doi.org/10.3390/pr2020345
Chicago/Turabian StyleGoodhart, J. Matthew, Jared O. Cooper, Richard A. Smith, John L. Williams, Warren O. Haggard, and Joel D. Bumgardner. 2014. "Design and Validation of a Cyclic Strain Bioreactor to Condition Spatially-Selective Scaffolds in Dual Strain Regimes" Processes 2, no. 2: 345-360. https://doi.org/10.3390/pr2020345