Kinetic Investigation of the Oxidative Thermal Decomposition of Levonorgestrel
Abstract
:1. Introduction
2. Materials and Methods
2.1. Samples and Preparation
2.2. FTIR Analysis
2.3. Thermal Analysis
2.4. Kinetic Analysis
3. Results and Discussion
3.1. FTIR Analysis
3.2. Thermal Analysis
3.3. Kinetic Investigations
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Sample | Decomposition Step | Ti (°C) | Tf (°C) | Tmax·DTG (°C) | Tpeak·DSC (°C) | Δm (%) |
---|---|---|---|---|---|---|
LNG | I | 192 | 355 | 306 | 243 | 28.3 |
II | 355 | 483 | 433; 443 | - | 41.04 | |
LNGTAB | I | 50 | 115 | 68 | 67.1 | 1.8 |
II | 115 | 165 | 151 | 149.8 | 3.72 | |
III | 165 | 267 | 242 | 215; 229 | 19.9 | |
IV | 267 | 384 | 306 | - | 45.4 | |
LNGMIX | I | 51 | 110 | 71 | - | 0.48 |
II | 110 | 178 | 151 | 149 | 1.88 | |
III | 178 | 263 | 233; 248 | 214; 238 | 13.34 | |
IV | 263 | 380 | 297 | - | 32.61 | |
V | 380 | 466 | 418; 427 | - | 17.17 | |
Lactose monohydrate | I | 100 | 171 | 146 | 147 | 4.99 |
II | 218 | 264 | 236 | 220; 239 | 8.7 | |
III | 264 | 391 | 306 | - | 60.6 | |
Silicon dioxide | - | - | - | - | - | - |
Magnesium stearate | I | 68 | 117 | 101 | 91; 116 | 3.24 |
II | 204 | 437 | 404; 413 | - | 76.44 | |
III | 437 | 520 | 460 | - | 10.18 | |
Starch | I | 30 | 141 | 72 | 105 | 10.11 |
II | 228 | 346 | 303 | - | 59.12 | |
Talc | - | - | - | - | - | - |
β (°C·min−1) | DTG Temperature Interval for “Process 1” (°C) for Kinetic Analysis of Samples | |
---|---|---|
LNG | LNGMIX | |
2 | 182–288 | 164–345 |
4 | 184–313 | 169–356 |
6 | 184–322 | 173–368 |
8 | 187–327 | 177–378 |
10 | 192–355 | 178–380 |
α | Variation in Ea (kJ·mol−1) vs. α for Process 1 for | |||
---|---|---|---|---|
LNG | LNGMIX | |||
FR | FWO | FR | FWO | |
0.05 | 99.1 | 153.8 | 145.1 | 175.6 |
0.1 | 82.7 | 122.1 | 124.9 | 152.1 |
0.15 | 80.8 | 110.9 | 119.7 | 141.1 |
0.2 | 82.3 | 105.3 | 115.1 | 133.9 |
0.25 | 84.8 | 102.2 | 112.3 | 128.4 |
0.3 | 87.3 | 100.4 | 111.9 | 124.5 |
0.35 | 89.5 | 99.4 | 111.5 | 121.7 |
0.4 | 91.1 | 98.8 | 110.8 | 119.7 |
0.45 | 91.9 | 98.5 | 112.7 | 118.6 |
0.5 | 91.9 | 98.2 | 115.6 | 118.4 |
0.55 | 91.5 | 98.0 | 119.3 | 118.9 |
0.6 | 91.0 | 97.8 | 125.6 | 120.1 |
0.65 | 90.5 | 97.5 | 133.9 | 122.4 |
0.7 | 90.1 | 97.3 | 144.9 | 126.2 |
0.75 | 89.9 | 97.0 | 158.7 | 132.1 |
0.8 | 89.9 | 96.7 | 171.5 | 140.5 |
0.85 | 89.8 | 96.3 | 172.6 | 149.7 |
0.9 | 89.6 | 95.9 | 151.4 | 154.0 |
0.95 | 89.1 | 95.2 | 110.3 | 144.5 |
Ēa/kJ·mol−1 | 89 ± 1 | 103 ± 3 | 130 ± 5 | 134 ± 4 |
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Ridichie, A.; Ledeţi, A.; Peter, F.; Ledeţi, I.; Muntean, C.; Rădulescu, M. Kinetic Investigation of the Oxidative Thermal Decomposition of Levonorgestrel. Processes 2023, 11, 3210. https://doi.org/10.3390/pr11113210
Ridichie A, Ledeţi A, Peter F, Ledeţi I, Muntean C, Rădulescu M. Kinetic Investigation of the Oxidative Thermal Decomposition of Levonorgestrel. Processes. 2023; 11(11):3210. https://doi.org/10.3390/pr11113210
Chicago/Turabian StyleRidichie, Amalia, Adriana Ledeţi, Francisc Peter, Ionuţ Ledeţi, Cornelia Muntean, and Matilda Rădulescu. 2023. "Kinetic Investigation of the Oxidative Thermal Decomposition of Levonorgestrel" Processes 11, no. 11: 3210. https://doi.org/10.3390/pr11113210