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Volume 10
Issue 2
10.3390/pr10020208
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Article

Chemical Characterization and Preliminary Evaluation of the Efficacy and Tolerability of a Food Supplement Based on Pomegranate Extract, B Vitamins, and Vitamin C against Prolonged Fatigue in Healthy Consumers

by
Cristina Esposito
1,
Cristina Santarcangelo
1,
Alessandro Di Minno
1,
Roberto Sacchi
2,
Eduardo Sommella
3,
Lorenza Francesca De Lellis
1,
Maria Antonietta De Pasquale
1,
Francesca Montarolo
1,
Pietro Campiglia
3,4,
Alessandra Baldi
5,
Costanza Riccioni
6 and
Maria Daglia
1,7,*
1
Department of Pharmacy, University of Naples Federico II, 80131 Naples, NA, Italy
2
Applied Statistic Unit, Department of Earth and Environmental Sciences, University of Pavia, 27100 Pavia, PV, Italy
3
Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy
4
European Biomedical Research Institute of Salerno, 84125 Salerno, SA, Italy
5
Tefarco Innova, National Inter-University Consortium of Innovative Pharmaceutical Technologies, 43124 Parma, PR, Italy
6
R&D Department, Esserre Pharma Srl, 00191 Rome, RM, Italy
7
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
*
Author to whom correspondence should be addressed.
Academic Editor: Ángeles Alonso-Moraga
Processes 2022, 10(2), 208; https://doi.org/10.3390/pr10020208
Received: 8 December 2021 / Revised: 7 January 2022 / Accepted: 18 January 2022 / Published: 22 January 2022
(This article belongs to the Special Issue Secondary Metabolites: Extraction, Optimization, Identification and Applications in Food, Nutraceutical, and Pharmaceutical Industries)
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Abstract

Fatigue, characterized by periods of exhaustion that interfere with normal activities and negatively affect quality of life, can be classified as prolonged fatigue (or short-term fatigue, SF) or chronic fatigue. Vitamin deficiency and chronic inflammation seem to be possible causes of fatigue. Due to the unavailability of effective remedies that attenuate fatigue and provide consumer satisfaction, the aim of this investigation is to assess whether a commercial food supplement consisting of pomegranate extract with known anti-inflammatory activity, B vitamins, and vitamin C can help fight SF. To this end, the chemical composition of whole fruit pomegranate dry extract was determined through a RP-UHPLC–HRMS method, which indicated the presence of ellagitannins, gallotannins, and organic and phenolic acids. In a survey of consumers of food supplements aimed at reducing fatigue, 78 subjects (21 men and 57 women) were recruited for one month to evaluate the efficacy and tolerability of this food supplement through validated questionnaires for assessing fatigue level and quality of life. The consumers reported a significant improvement in their conditions without adverse effects over this time period. Although further studies are needed, these preliminary data suggest the capacity of a combination of pomegranate extract and hydrosoluble vitamins to alleviate SF. View Full-Text
Keywords: pomegranate extract; metabolic profiling; vitamin C; B vitamins; prolonged fatigue; healthy subjects pomegranate extract; metabolic profiling; vitamin C; B vitamins; prolonged fatigue; healthy subjects
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MDPI and ACS Style

Esposito, C.; Santarcangelo, C.; Di Minno, A.; Sacchi, R.; Sommella, E.; De Lellis, L.F.; De Pasquale, M.A.; Montarolo, F.; Campiglia, P.; Baldi, A.; Riccioni, C.; Daglia, M. Chemical Characterization and Preliminary Evaluation of the Efficacy and Tolerability of a Food Supplement Based on Pomegranate Extract, B Vitamins, and Vitamin C against Prolonged Fatigue in Healthy Consumers. Processes 2022, 10, 208. https://doi.org/10.3390/pr10020208

AMA Style

Esposito C, Santarcangelo C, Di Minno A, Sacchi R, Sommella E, De Lellis LF, De Pasquale MA, Montarolo F, Campiglia P, Baldi A, Riccioni C, Daglia M. Chemical Characterization and Preliminary Evaluation of the Efficacy and Tolerability of a Food Supplement Based on Pomegranate Extract, B Vitamins, and Vitamin C against Prolonged Fatigue in Healthy Consumers. Processes. 2022; 10(2):208. https://doi.org/10.3390/pr10020208

Chicago/Turabian Style

Esposito, Cristina, Cristina Santarcangelo, Alessandro Di Minno, Roberto Sacchi, Eduardo Sommella, Lorenza F. De Lellis, Maria A. De Pasquale, Francesca Montarolo, Pietro Campiglia, Alessandra Baldi, Costanza Riccioni, and Maria Daglia. 2022. "Chemical Characterization and Preliminary Evaluation of the Efficacy and Tolerability of a Food Supplement Based on Pomegranate Extract, B Vitamins, and Vitamin C against Prolonged Fatigue in Healthy Consumers" Processes 10, no. 2: 208. https://doi.org/10.3390/pr10020208

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