Ultra Short Course Chemotherapy for Early-Stage Non-Hodgkin’s Lymphoma in Children
Abstract
:1. Introduction
2. Material and Methods
2.1. Patients
2.2. Treatment
2.3. Response Criteria and Follow-Up
2.4. Statistics
3. Results
3.1. Patients
3.2. Response to Treatment
3.3. Disease Relapse
3.4. Survival
3.5. Toxicities
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Protocol I | Protocol II | All | |
---|---|---|---|
No. of patients | 21 | 25 | 46 |
Median age, years (range) | 10, 9 (2.2–18.5) | 9, 2 (4.3–19.8) | 10, 3 (2.2–19.8) |
Male:Female | 12:9 | 13:12 | 25:21 |
“Resected” tumor at diagnosis | 12 | 14 | 26 |
Histological Classification | |||
Burkitt L | 10 | 15 | 25 |
Precursor B lymphoblastic L | 3 | 2 | 5 |
MALT L | 3 | 1 | 4 |
DLBCL | 3 | 5 | 8 |
ALCL | 2 | 0 | 2 |
Follicular lymphoma | 0 | 1 | 1 |
Not-otherwised-specified high–grade B lymphoma | 0 | 1 | 1 |
Relapses/failure to induction | 5 | 2 | 7 |
Death related to L | 1 | 0 | 1 |
Death for other causes | 2 | 1 | 3 |
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Schiavello, E.; Spreafico, F.; Barretta, F.; Meraviglia, G.; Biassoni, V.; Terenziani, M.; Boschetti, L.; Gattuso, G.; Chiaravalli, S.; Bergamaschi, L.; et al. Ultra Short Course Chemotherapy for Early-Stage Non-Hodgkin’s Lymphoma in Children. Children 2022, 9, 1279. https://doi.org/10.3390/children9091279
Schiavello E, Spreafico F, Barretta F, Meraviglia G, Biassoni V, Terenziani M, Boschetti L, Gattuso G, Chiaravalli S, Bergamaschi L, et al. Ultra Short Course Chemotherapy for Early-Stage Non-Hodgkin’s Lymphoma in Children. Children. 2022; 9(9):1279. https://doi.org/10.3390/children9091279
Chicago/Turabian StyleSchiavello, Elisabetta, Filippo Spreafico, Francesco Barretta, Giulia Meraviglia, Veronica Biassoni, Monica Terenziani, Luna Boschetti, Giovanna Gattuso, Stefano Chiaravalli, Luca Bergamaschi, and et al. 2022. "Ultra Short Course Chemotherapy for Early-Stage Non-Hodgkin’s Lymphoma in Children" Children 9, no. 9: 1279. https://doi.org/10.3390/children9091279