The Role of Elevated Wall Shear Stress in Progression of Pulmonary Vein Stenosis: Evidence from Two Case Studies
Abstract
:1. Introduction
2. Materials and Methods
2.1. Calculation of Wall Shear Stress from Clinical Data
2.2. Case 1
2.3. Case 2
3. Results
3.1. Case 1
3.2. Case 2
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Age Months | BSA m2 | CI L/min/m2 | Qp:Qs | QL/QR | 2a mm | 2b mm | Τ dyn/cm2 | Re | dτ = 10 mm | |
---|---|---|---|---|---|---|---|---|---|---|
4 | 0.22 | 3.2 | 1.8 | 58/42 | 3.3 | 1.8 | 204 | 898 | 6.0 | LUPV |
3.0 | 2.6 | 108 | 835 | 6.0 | LLPV | |||||
4.8 | 3.9 | 43 | 777 | 6.8 | RLPV | |||||
10 | 0.30 | 2.8 | 1.8 | 35/65 | 2.9 | 1.4 | 277 | 760 | 5.4 | LUPV |
2.7 | 1.9 | 161 | 727 | 5.4 | LLPV | |||||
5.8 | 4.4 | 52 | 1221 | 8.4 | RLPV | |||||
14 | 0.33 | 4.0 | 1.0 | 40/60 | 1.9 | 1.8 | 255 | 908 | 5.4 | LUPV |
4.3 | 2.5 | 58 | 486 | 5.4 | LLPV | |||||
5.1 | 4.7 | 42 | 1029 | 7.8 | RLPV | |||||
22 | 0.45 | 3.4 | 1.0 | 44/56 | 2.8 | 2.4 | 124 | 823 | 5.8 | LUPV |
4.7 | 4.4 | 22 | 471 | 5.8 | LLPV | |||||
4.7 | 4.3 | 59 | 1212 | 8.0 | RLPV | |||||
23.5 | 0.46 | 3.4 | 1.0 | 44/56 | 3.1 | 2.7 | 90 | 754 | 5.9 | LUPV |
5.5 | 4.1 | 22 | 454 | 5.9 | LLPV | |||||
4.7 | 4.2 | 63 | 1252 | 8.0 | RLPV |
Age Months | BSA m2 | CI L/min/m2 | Qp:Qs | QL/QR | 2a mm | 2b mm | τ dyn/cm2 | Re | dτ=10 mm | |
---|---|---|---|---|---|---|---|---|---|---|
6 | 0.28 | 3.2 | 2.6 | 80/20 | 5.2 | 2.1 | 241 | 1554 | 8.2 | LUPV |
5.1 | 3.9 | 71 | 1312 | 8.2 | LLPV | |||||
1.8 | 1.8 | 475 | 1648 | 6.5 | RLPV | |||||
10 | 0.33 | 3.3 | 1.0 | 52/48 | 4.2 | 2.0 | 100 | 564 | 5.5 | LUPV |
5.2 | 2.0 | 40 | 435 | 5.5 | LLPV | |||||
4.3 | 3.0 | 80 | 905 | 6.8 | RLPV | |||||
17 | 0.39 | 4.2 | 1.0 | 52/48 | 2.9 | 2.0 | 218 | 1097 | 6.3 | LUPV |
5.6 | 2.8 | 58 | 628 | 6.3 | LLPV | |||||
4.9 | 3.7 | 70 | 1158 | 7.8 | RLPV | |||||
22 | 0.42 | 5.2 | 0.8 | 44/56 | - | - | - | - | - | LUPV |
4.3 | 2.8 | 135 | 1363 | 7.7 | LLPV | |||||
5.0 | 4.5 | 57 | 1310 | 8.3 | RLPV | |||||
27 | 0.45 | 4.1 | 1.0 | 37/63 | - | - | - | - | - | LUPV |
3.2 | 2.7 | 174 | 1471 | 7.4 | LLPV | |||||
5.8 | 4.7 | 54 | 1406 | 8.8 | RLPV | |||||
- | - | - | - | - | LUPV | |||||
34 | 0.48 | 3.0 | 1.0 | 34/66 | 2.5 | 2.5 | 186 | 1247 | 6.6 | LLPV |
5.9 | 4.6 | 45 | 1148 | 8.3 | RLPV | |||||
- | - | - | - | - | LUPV | |||||
41 | 0.52 | 2.9 | 1.0 | 39/61 | 3.1 | 2.1 | 256 | 1427 | 7.0 | LLPV |
6.0 | 2.3 | 172 | 1344 | 8.2 | RLPV | |||||
- | - | - | - | - | LUPV | |||||
47 | 0.55 | 3.1 | 1.0 | 35/65 | 4.0 | 2.9 | 105 | 1094 | 7.1 | LLPV |
7.1 | 3.9 | 61 | 1256 | 8.7 | RLPV | |||||
- | - | - | - | - | LUPV | |||||
57 | 0.64 | 3.0 | 1.0 | 35/65 | 7.2 | 7.0 | 11 | 603 | 7.4 | LLPV |
7.5 | 4.3 | 53 | 1322 | 9.1 | RLPV | |||||
- | - | - | - | - | LUPV | |||||
132 | 1.36 | 3.1 | 1.0 | 49/51 | 10.0 | 8.6 | 17 | 1412 | 10.7 | LLPV |
10.4 | 6.6 | 28 | 1591 | 10.9 | RLPV |
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Hammer, P.E.; McEnaney, K.; Callahan, R.; Baird, C.W.; Hoganson, D.M.; Jenkins, K.J. The Role of Elevated Wall Shear Stress in Progression of Pulmonary Vein Stenosis: Evidence from Two Case Studies. Children 2021, 8, 729. https://doi.org/10.3390/children8090729
Hammer PE, McEnaney K, Callahan R, Baird CW, Hoganson DM, Jenkins KJ. The Role of Elevated Wall Shear Stress in Progression of Pulmonary Vein Stenosis: Evidence from Two Case Studies. Children. 2021; 8(9):729. https://doi.org/10.3390/children8090729
Chicago/Turabian StyleHammer, Peter E., Kerry McEnaney, Ryan Callahan, Christopher W. Baird, David M. Hoganson, and Kathy J. Jenkins. 2021. "The Role of Elevated Wall Shear Stress in Progression of Pulmonary Vein Stenosis: Evidence from Two Case Studies" Children 8, no. 9: 729. https://doi.org/10.3390/children8090729