Management of Central Precocious Puberty in Children with Hypothalamic Hamartoma
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Study Design
2.3. Statistical Analysis
3. Results
3.1. Clinical Characteristics of Patients with HH
3.2. Association between Clinical Manifestations and Type of HH
3.3. Management of Central Precocious Puberty in HH Patients
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Value |
---|---|
Sex | |
Male/Female | 14 (46.7%)/16 (53.3%) |
Age at symptom onset (year) | 2.9 ± 2.5 |
Age at diagnosis (year) | 4.2 ± 2.9 |
Symptom at first visit | |
Precocious puberty | 12 (40.0%) |
Gelastic seizure | 9 (30.0%) |
Other seizures | 7 (23.3%) |
Headache | 1 (3.3%) |
Developmental delay | 1 (3.3%) |
Symptoms during follow-up | |
Precocious puberty | 24 (80.0%) |
Gelastic seizure | 15 (50.0%) |
Developmental delay | 13 (43.3%) |
Treatment | |
Surgical operation | 12 (40.0%) |
Gamma-knife surgery | 2 (6.7%) |
GnRH agonist treatment | 24/24 (100%) |
Growth hormone treatment | 2 (6.7%) |
Type of hypothalamic hamartoma | |
Pedunculated/Sessile | 16 (53.3%)/14 (46.7%) |
Size of hypothalamic hamartoma (mm) | 17.8 ± 9.2 |
Sessile Type | Pedunculated Type | p Value | |
---|---|---|---|
Precocious puberty | 10/14 (71.4%) | 14/16 (87.5%) | 0.378 |
Gelastic seizure | 12/14 (85.7%) | 3/16 (18.8%) | 0.001 |
Developmental delay | 9/14 (64.3%) | 4/16 (25.0%) | 0.063 |
Characteristics | Value |
---|---|
Male/female | 11 (45.8%)/13 (54.2%) |
Age at diagnosis of CPP (year) | 5.7 ± 3.1 |
Basal hormone levels at diagnosis | |
LH (IU/L) | 2.48 ± 1.31 |
FSH (IU/L) | 4.18 ± 2.73 |
Estradiol (pg/mL) (n = 13) | 25.74 ± 23.00 |
Testosterone (ng/dL) (n = 11) | 227.26 ± 291.82 |
Prolactin (ng/mL) | 12.95 ± 7.50 |
LH peak of GnRH stimulation test (IU/L) | 27.92 ± 18.94 |
Breast tanner stage on diagnosis of CPP (n = 13) | 2.8 ± 0.6 |
Testis size on diagnosis of CPP (cc) (n = 11) | 12.1 ± 7.1 |
Duration of GnRH agonist treatment (year) (n = 15) | 3.1 ± 2.2 |
Before GnRH Treatment | After GnRH Treatment | p Value | |
---|---|---|---|
Height (cm) | 123.7 ± 19.4 | 141.0 ± 15.0 | <0.001 |
Height SDS for chronological age | 1.38 ± 1.76 | 0.72 ± 1.38 | 0.010 |
Height SDS for bone age | −2.65 ± 1.76 | −1.43 ± 1.15 | 0.003 |
Weight (kg) | 30.9 ± 12.4 | 44.8 ± 12.6 | <0.001 |
Weight SDS | 1.53 ± 1.17 | 1.41 ± 0.88 | 0.450 |
BMI | 19.30 ± 2.88 | 22.29 ± 3.37 | 0.001 |
BMI SDS | 1.23 ± 1.26 | 1.58 ± 0.94 | 0.214 |
Bone age (year) | 9.9 ± 2.3 | 11.7 ± 1.9 | <0.001 |
Chronological age (year) | 6.6 ± 3.0 | 9.7 ± 2.7 | <0.001 |
BA–CA (year) | 3.3 ± 1.3 | 2.0 ± 1.7 | 0.002 |
Male predicted adult height (cm) (n = 6) | 171.0 ± 12.4 | 175.2 ± 8.3 | 0.066 |
Female predicted adult height (cm) (n = 7) | 149.0 ± 8.8 | 157.3 ± 9.7 | 0.006 |
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Suh, J.; Choi, Y.; Oh, J.S.; Song, K.; Choi, H.S.; Kwon, A.; Chae, H.W.; Kim, H.-S. Management of Central Precocious Puberty in Children with Hypothalamic Hamartoma. Children 2021, 8, 711. https://doi.org/10.3390/children8080711
Suh J, Choi Y, Oh JS, Song K, Choi HS, Kwon A, Chae HW, Kim H-S. Management of Central Precocious Puberty in Children with Hypothalamic Hamartoma. Children. 2021; 8(8):711. https://doi.org/10.3390/children8080711
Chicago/Turabian StyleSuh, Junghwan, Youngha Choi, Jun Suk Oh, Kyungchul Song, Han Saem Choi, Ahreum Kwon, Hyun Wook Chae, and Ho-Seong Kim. 2021. "Management of Central Precocious Puberty in Children with Hypothalamic Hamartoma" Children 8, no. 8: 711. https://doi.org/10.3390/children8080711