Iatrogenic Blood Loss in Very Low Birth Weight Infants and Transfusion of Packed Red Blood Cells in a Tertiary Care Neonatal Intensive Care Unit
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Patients
3.2. Blood Transfusion
3.3. Blood Sampling
3.4. Risk Factors for Necessity of Transfusion
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study Population (n = 132) | |
---|---|
Birth weight [g, median, IQR, range] | 1180 (IQR 903–1360, range 370–1495) |
Gestational age [weeks, median, IQR, range] | 29 + 5 (IQR 27 + 5 to 31 + 2; range 23 + 5 to 36 + 5) |
LOS [days, median, IQR, range] | 54 (IQR 35–74; range 0–154) |
Multiple gestation [n; %] | 66 (50%) |
Female sex [n; %] | 63 (47.7%) |
Delivery mode C-section | 121 (91.7%) |
Sepsis/Infection [n; %] | 39 (29.5%) |
IVH [n; %] | 6 (4.5%) |
BPD [n; %] | 6 (4.5%) |
ROP [n; %] | 6 (4.5%) |
NEC [n; %] | 4 (3.0%) |
PDA treated medically | 28 (21.2%) |
PDA treated operatively [n; %] | 4 (3.0%) |
Fatal outcome [n; %] | 6 (4.5%) |
Demographic Factor | Transfused Patients (n = 42) | Non-Transfused Patients (n = 90) | p (t-Test) |
---|---|---|---|
Birth weight [g, median, IQR] | 755 (643–943) | 1275 (1074–1415) | <0.001 |
Gestational age [weeks, median, IQR] | 26 + 2 (25 + 3 − 29 + 5) | 30 + 2 (28 + 5 − 31 + 5) | <0.001 |
LOS [days, median, IQR] | 93 (70–103) | 44 (33–59) | <0.001 |
Postnatal Age [Completed Weeks] | Non-Transfused Patients [mL; Median (IQR)] | Transfused Patients [mL; Median (IQR)] |
---|---|---|
0 | 6.18 (4.73–7.35) | 8.20 (6.60–9.95) |
1 | 8.65 (7.23–10.53) | 11.50 (9.35–14.75) |
2 | 10.33 (8.43–12.69) | 14.98 (11.86–18.95) |
3 | 12.45 (10.39–14.01) | 17.15 (13.90–26.50) |
4 | 14.00 (12.05–16.20) | 21.60 (17.51–29.40) |
5 | 15.50 (13.49–17.71) | 22.10 (17.88–32.89) |
6 | 17.68 (15.93–20.64) | 23.20 (19.10–35.95) |
7 | 19.45 (17.30–21.25) | 25.50 (21.03–35.86) |
8 | 20.90 (18.74–24.84) | 30.83 (23.25–41.79) |
9 | 26.45 (21.45–29.45) | 34.63 (25.40–44.35) |
10 | 31.45 (29.10–33.25 | 37.28 (25.11–47.11) |
11 | 33.60 (32.08–35.13) | 39.45 (29.50–49.00) |
12 | 36.80 (35.25–37.60) | 41.45 (31.38–53.75) |
13 | 36.23 (35.01–37.44) | 44.70 (34.70–55.10) |
14 | 49.75 (43.99–60.01) | |
15 | 59.90 (45.70–70.05) | |
16 | 65.60 (62.65–87.35) | |
17 | 89.90 (77.13–123.05) | |
18 | 90.10 (78.80–124.13) | |
19 | 92.15 (80.75–126.50) | |
20 | 126.60 (109.43–143.78) |
Factor | Likelihood Ratio (Fisher’s Exact Test) | p |
---|---|---|
Sex | 0.127 | 0.852 (n.s.) |
Multiple gestation | 0.127 | 0.852 (n.s.) |
Delivery mode | 0.140 | 0.740 (n.s.) |
IVH | 3.216 | 0.081 (n.s.) |
BPD | 7.165 | 0.012 * |
Mortality | 7.165 | 0.012 * |
ROP | 7.165 | 0.012 * |
PDA treated operatively | 9.432 | 0.009 * |
NEC | 9.432 | 0.009 * |
PDA treated medically | 12.892 | 0.000 * |
Sepsis/Infection | 30.087 | 0.000 * |
Gestational age | 92.743 | 0.001 * |
Length of stay | 131.353 | 0.000 * |
Birth weight | 136.013 | 0.000 * |
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Aboalqez, A.; Deindl, P.; Ebenebe, C.U.; Singer, D.; Blohm, M.E. Iatrogenic Blood Loss in Very Low Birth Weight Infants and Transfusion of Packed Red Blood Cells in a Tertiary Care Neonatal Intensive Care Unit. Children 2021, 8, 847. https://doi.org/10.3390/children8100847
Aboalqez A, Deindl P, Ebenebe CU, Singer D, Blohm ME. Iatrogenic Blood Loss in Very Low Birth Weight Infants and Transfusion of Packed Red Blood Cells in a Tertiary Care Neonatal Intensive Care Unit. Children. 2021; 8(10):847. https://doi.org/10.3390/children8100847
Chicago/Turabian StyleAboalqez, Ahmed, Philipp Deindl, Chinedu Ulrich Ebenebe, Dominique Singer, and Martin Ernst Blohm. 2021. "Iatrogenic Blood Loss in Very Low Birth Weight Infants and Transfusion of Packed Red Blood Cells in a Tertiary Care Neonatal Intensive Care Unit" Children 8, no. 10: 847. https://doi.org/10.3390/children8100847