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Article

Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania

1
2nd Pediatric Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400012 Cluj-Napoca, Romania
2
Center of Expertise in Pediatric Liver Rare Disorders, 2nd Pediatric Clinic, Emergency Clinic Hospital for Children, 400177 Cluj-Napoca, Romania
3
University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania
4
Pediatric Nephrology, Dialysis and Toxicology Clinic, Emergency Clinic Hospital for Children, 400177 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Children 2020, 7(12), 282; https://doi.org/10.3390/children7120282
Received: 28 September 2020 / Revised: 4 December 2020 / Accepted: 6 December 2020 / Published: 9 December 2020
Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in emergencies. Methods: We have analyzed the etiology and outcome of ALF in children followed-up in a tertiary care hospital between January 2012–December 2018. The patients were grouped into different age categories: neonates (0–1 month), infants (1–12 months), children (1–14 years), and teenagers (14–18 years). Results: 97 children (46 males, 47.42%, the mean age of 7.66 ± 8.18 years) were admitted with ALF. The most important causes of ALF were in neonates and infants, infections (72.72%), and metabolic disorders (43.47%), in children and adolescents were the toxic causes (60% and 79.41%). The mortality rate was 31.95% (31 patients), mainly in ALF due to infections or metabolic disorders. Conclusions: In neonates and infants, the main causes of ALF were infections and metabolic diseases, while in older children and teenagers, were toxin-induced liver injuries. The mortality among neonates and infants was significantly higher than in other ages. Early recognition and immediate therapeutic intervention could improve the outcome of these patients. View Full-Text
Keywords: acute liver failure; children; teenagers; etiology; outcome acute liver failure; children; teenagers; etiology; outcome
MDPI and ACS Style

Grama, A.; Aldea, C.O.; Burac, L.; Delean, D.; Bulata, B.; Sirbe, C.; Duca, E.; Boghitoiu, D.; Coroleuca, A.; Pop, T.L. Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania. Children 2020, 7, 282. https://doi.org/10.3390/children7120282

AMA Style

Grama A, Aldea CO, Burac L, Delean D, Bulata B, Sirbe C, Duca E, Boghitoiu D, Coroleuca A, Pop TL. Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania. Children. 2020; 7(12):282. https://doi.org/10.3390/children7120282

Chicago/Turabian Style

Grama, Alina, Cornel Olimpiu Aldea, Lucia Burac, Dan Delean, Bogdan Bulata, Claudia Sirbe, Emanuela Duca, Dora Boghitoiu, Alexandra Coroleuca, and Tudor Lucian Pop. 2020. "Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania" Children 7, no. 12: 282. https://doi.org/10.3390/children7120282

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