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Case Report

Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with Beta-Thalassemia Minor for Severe Aplastic Anemia

1
Department of Pediatrics, Yeungnam University College of Medicine, Daegu 42415, Korea
2
Department of Pediatrics, Daegu Fatima Hospital, Daegu 41199, Korea
*
Author to whom correspondence should be addressed.
Children 2020, 7(10), 162; https://doi.org/10.3390/children7100162
Received: 7 September 2020 / Revised: 28 September 2020 / Accepted: 30 September 2020 / Published: 4 October 2020
(This article belongs to the Section Oncology and Hematology)
The first-line treatment for severe aplastic anemia (SAA) patients is hematopoietic stem cell transplantation (HSCT), with full-matched related donors considered the most suitable. We report a case of SAA in which the patient successfully underwent HSCT from a donor with β-thalassemia minor. The patient in this case underwent HSCT from a human leukocyte antigen (HLA)-matched younger brother with β-thalassemia minor. A 7-year-old girl was referred to our facility following a 6-month history of easy bruising and pallor. Laboratory examinations showed pancytopenia and hypocellular bone marrow with cellularity of <5%. She was diagnosed with acquired SAA, and HLA typing of her family members was performed. Her younger brother was an HLA-matched sibling but had β-thalassemia minor. Since his hemoglobin levels were maintained at 10–11 d/dL, he was considered a suitable HSCT donor. The conditioning regimen included fludarabine, cyclophosphamide, and anti-thymocyte globulin. The CD34+ and CD3+ cell counts were 6.6 × 106/kg and 0.48 × 108/kg, respectively. White blood cell engraftment was evident on day +11. Regimen-associated toxicities, such as anorexia and enteritis, were mild; no infections occurred, and no symptoms of acute graft-versus-host disease (GVHD) were observed. The 30-day follow-up bone marrow examination revealed normocellular marrow with 80%–90% cellularity. Acute or chronic GVHD has not been reported, and good performance status has been observed throughout the 5 years after HSCT. β-thalassemia minor patients can be considered as bone marrow donors for SAA patients. View Full-Text
Keywords: aplastic anemia; beta-thalassemia; thalassemia minor; hematopoietic stem cell transplantation aplastic anemia; beta-thalassemia; thalassemia minor; hematopoietic stem cell transplantation
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MDPI and ACS Style

Jung, M.Y.; Lim, Y.T.; Lim, H.; Hah, J.O.; Lee, J.M. Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with Beta-Thalassemia Minor for Severe Aplastic Anemia. Children 2020, 7, 162. https://doi.org/10.3390/children7100162

AMA Style

Jung MY, Lim YT, Lim H, Hah JO, Lee JM. Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with Beta-Thalassemia Minor for Severe Aplastic Anemia. Children. 2020; 7(10):162. https://doi.org/10.3390/children7100162

Chicago/Turabian Style

Jung, Mi Y., Young T. Lim, Hyunji Lim, Jeong O. Hah, and Jae M. Lee 2020. "Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with Beta-Thalassemia Minor for Severe Aplastic Anemia" Children 7, no. 10: 162. https://doi.org/10.3390/children7100162

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