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Children 2017, 4(9), 79; https://doi.org/10.3390/children4090079

Assessment of Initial Vancomycin Dosing in Pediatric Oncology Patients

1
Department of Pharmacy, Norton Children’s Hospital, Louisville, KY 40202, USA
2
Department of Pharmacy, Children’s Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX 77030, USA
3
Department of Pharmacy, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
4
Division of Pediatric Hematology-Oncology, University of Louisville, Louisville, KY 40202, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Paul Nathan
Received: 3 August 2017 / Revised: 23 August 2017 / Accepted: 23 August 2017 / Published: 28 August 2017
(This article belongs to the Section Oncology and Hematology)
Full-Text   |   PDF [185 KB, uploaded 28 August 2017]

Abstract

This was a retrospective audit assessing vancomycin dosing of 60 mg/kg/day in the attainment of therapeutic concentrations between 10–20 mcg/mL among 56 pediatric oncology patients. Twelve patients (21%) achieved therapeutic concentrations of 10–20 mcg/mL, while 44 patients (79%) obtained trough levels below 10 mcg/mL despite the addition of nephrotoxic agents. View Full-Text
Keywords: vancomycin; pediatrics; oncology; pharmacokinetics vancomycin; pediatrics; oncology; pharmacokinetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Orr, H.; Trone, D.; Elder, J.; Raj, A. Assessment of Initial Vancomycin Dosing in Pediatric Oncology Patients. Children 2017, 4, 79.

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