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Children 2017, 4(7), 54;

Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma

Division of Pulmonary and Sleep Medicine, Children’s National Health System, Washington 20010, DC, USA
Division of Pulmonary and Sleep Medicine, MedStar Georgetown University Hospital, Washington 20007, DC, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 9 May 2017 / Revised: 23 June 2017 / Accepted: 23 June 2017 / Published: 28 June 2017
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Up to 80% of asthmatic children may experience upper airway symptoms which are often perceived as coming from the lower airways. Currently, there are no validated questionnaires to assess upper airway contribution to pediatric asthma symptoms. The Sino-Nasal 5 (SN-5) questionnaire was previously validated for identifying radiographic confirmed sinus disease in children. In this study, we hypothesize that significant SN-5 scores (≥3.5) are associated with abnormal National Asthma Education and Prevention Program (NAEPP) based asthma impairment and control in asthmatic children. Retrospective data collected on children with asthma referred for pulmonary evaluation included age, gender, ethnicity, NAEPP asthma severity, asthma control (Test for Respiratory and Asthma Control in Kids (TRACK) < 5 years, Asthma Control Test (ACT) 5 years) and pulmonary function testing. Associations between SN-5 scores and asthma impairment and control were identified. Seventy-six children were evaluated; 38% were female with a mean age of 6.9 years. Significant SN-5 scores were associated with decreased control of daytime symptoms (odds ratio (OR): 0.16 (95% confidence interval (CI): 0.06–0.44)), night time awakenings (0.09 (0.03–0.29)), activity interference (0.2 (0.06–0.68)), NAEPP defined asthma control (0.32 (0.12–0.85)) and poor asthma control based on TRACK (p < 0.001) and ACT (p < 0.001). This suggests upper airways may play a larger role in perceived lower airway symptoms, and SN-5 may be beneficial in assessing the contribution of upper airway conditions on asthma control. View Full-Text
Keywords: asthma; rhinosinusitis; screening; Sino-Nasal 5 score asthma; rhinosinusitis; screening; Sino-Nasal 5 score

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Kilaikode, S.; Shukla, P.J.; Phull, G.; Jackson, J.H.; Prue, D.C.; Martinez, C.; Scheffey, K.; Pillai, D.K. Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma. Children 2017, 4, 54.

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