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Children 2017, 4(5), 34;

Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study

Laney Graduate School, Emory University, Atlanta, GA 30322, USA
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA
Children’s Healthcare of Atlanta, Atlanta, GA 30322, USA
Division of Pediatric Surgery, Department of Surgery, School of Medicine, Emory University, Atlanta, GA 30322, USA
Author to whom correspondence should be addressed.
Academic Editor: Lucia Pacifico
Received: 13 March 2017 / Revised: 13 April 2017 / Accepted: 26 April 2017 / Published: 3 May 2017
(This article belongs to the Special Issue Pediatric Nonalcoholic Fatty Liver Disease)
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Little is known regarding the subsequent course of non-alcoholic fatty liver disease (NAFLD) diagnosed in childhood. The objectives of this single-center study were to gather data on long-term health outcomes and to assess the feasibility of contacting former pediatric patients. In a large pediatric medical center, electronic records were searched to initially identify 162 former patients who had a liver biopsy between 2000 and 2010. Of these, 44 subjects met the criteria for age at follow-up (≥18 year) and biopsy-proven NAFLD, and were recruited via postal and electronic mail. Participants were invited to complete a brief telephone survey on current health status. Supplemental data was also obtained from pediatric medical charts of all subjects. At NAFLD diagnosis, 18% of subjects had diabetes, 91% were obese, 61% had NASH, and 56% had fibrosis on biopsy. At follow-up, 10 subjects (23%) responded to the survey. Based on the survey and chart review, after a mean follow-up of 4.5 years, 5 additional subjects developed diabetes for a period prevalence of 30%, and most subjects (78%) remained obese at last follow-up. Additional prospective studies are needed to fully describe the longitudinal risks associated with pediatric NAFLD, and will require multi-dimensional strategies to successfully recruit former patients. View Full-Text
Keywords: adolescence; BMI; hepatic; metabolic syndrome; longitudinal adolescence; BMI; hepatic; metabolic syndrome; longitudinal

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Cioffi, C.E.; Welsh, J.A.; Cleeton, R.L.; Caltharp, S.A.; Romero, R.; Wulkan, M.L.; Konomi, J.V.; Frediani, J.K.; Vos, M.B. Natural History of NAFLD Diagnosed in Childhood: A Single-Center Study. Children 2017, 4, 34.

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