Precision Medicine for Acute Lymphoblastic Leukemia in Children: A Review
Abstract
:1. Introduction
2. Favorable and Unfavorable Genotypes in ALL: Past, Present and Future
3. Philadelphia Chromosome-Positive ALL
4. Philadelphia Chromosome-like ALL
5. Infant ALL
6. Hypodiploid ALL
7. MEF2D-R ALL and HDAC Inhibitors
8. T Lymphoblastic Leukemia
9. Immunotherapy
10. Pharmacogenomics
11. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ALL Subtype | Targeted Therapy |
---|---|
Ph+ ALL | imatinib, dasatinib, nilotinib, ponatinib |
Ph-like ALL | |
with JAK-STAT pathway mutations | ruxolitinib |
with ABL or PDGFR mutations | imatinib, dasatinib |
with NTRK fusions | larotrectinib |
KMT2A-rearranged ALL | lestaurtinib, revumenib |
Hypodiploid ALL | venetoclax |
MEF2D-rearranged ALL | panobinostat |
T-ALL | daratumomab |
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Ray, A.; Levitt, M.; Efunkoya, T.; Trinkman, H. Precision Medicine for Acute Lymphoblastic Leukemia in Children: A Review. Children 2024, 11, 1329. https://doi.org/10.3390/children11111329
Ray A, Levitt M, Efunkoya T, Trinkman H. Precision Medicine for Acute Lymphoblastic Leukemia in Children: A Review. Children. 2024; 11(11):1329. https://doi.org/10.3390/children11111329
Chicago/Turabian StyleRay, Anish, Michael Levitt, Toluwalope Efunkoya, and Heidi Trinkman. 2024. "Precision Medicine for Acute Lymphoblastic Leukemia in Children: A Review" Children 11, no. 11: 1329. https://doi.org/10.3390/children11111329
APA StyleRay, A., Levitt, M., Efunkoya, T., & Trinkman, H. (2024). Precision Medicine for Acute Lymphoblastic Leukemia in Children: A Review. Children, 11(11), 1329. https://doi.org/10.3390/children11111329