Neurodevelopmental Outcome of Very Low Birth Weight Infants in the Northern District of Israel: A Cross-Sectional Study
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Number (Percent) N = 436 | |
---|---|---|
Sex | Male | 220 (50.5) |
Female | 216 (49.5) | |
Ethnicity | Jewish | 248 (56.8) |
Non-Jewish | 187 (42.8) | |
Mode of delivery | Vaginal | 75 (17.5) |
Cesarean section | 359 (82.5) | |
Multiple gestation | 193 (44.3) | |
Birth weight, g (mean ± SD) | 1132 ± 242 | |
Weight percentile | SGA | 89 (20.4) |
AGA | 341 (78.2) | |
LGA | 6 (1.3) | |
Gestational age, weeks (mean ± SD) | 29.5 ± 2.6 | |
Gestational age | 23–27 + 6 weeks | 109 (25.0) |
28–31 + 6 weeks | 230 (52.7) | |
>32 weeks | 97 (22.2) | |
Complications of prematurity | ||
NEC | 29 (6.7) * | |
BPD | 115 (26.5) * | |
LOS | 64 (14.7) * | |
ROP | 36 (8.3) ** | |
IVH grade 3 | 15 (3.4) | |
IVH grade 4 | 9 (2.1) | |
PHH | 13 (2.9) | |
WMI | 25 (5.8) | |
Cystic WMI | 16 (3.6) |
Variable | Number (Percent) N = 436 |
---|---|
No neurodevelopmental impairment | 241/436 (55.1) |
Cerebral palsy | 39/436 (8.9) |
Hemiplegic | 8/436 (1.8) |
Diplegic | 13/436 (3) |
Quadriplegic | 14/436 (3.2) |
Global developmental delay | 53/433 (12.2) |
Autism spectrum disorder | 7/436 (1.6) |
Attention deficit and hyperactivity disorder | 34/436 (7.8) |
Language delay | 145/434 (33.4) |
Developmental coordination disorder | 16/434 (3.7) |
Deafness | 6/433 (1.4) |
Blindness | 2/432 (0.5) |
Gestational Age (Weeks) | Normal Developmental Outcome | Cerebral Palsy | Global Developmental Delay | Autism Spectrum Disorder | Language Delay |
---|---|---|---|---|---|
23–27 + 6 weeks | 43/109 (40.3) | 22/109 (20.2) | 24/109 (22) | 3/109 (2.8) | 49/109 (44.9) |
28–31 + 6 weeks | 136/230 (59.1) | 13/230 (5.7) | 21/230 (9.1) | 4/230 (1.7) | 65/230 (28.2) |
>32 weeks | 56/97 (57.7) | 4/97 (4.1) | 8/97 (8.2) | 0/97 (0) | 32/97 (33) |
Neurodevelopmental Outcome | IVH | WMI | PHH | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
No IVH n = 364 | Low-Grade IVH n = 48 | High-Grade IVH n = 24 | p-value | No WMI n = 411 | Low-Grade WMI n = 9 | Cystic WMI n = 16 | p-value | No PHH n = 423 | PHH n = 13 | p-Value | |
CP n (%) | 22 (6.0) | 3 (6.3) | 14 (58.3) | <0.0001 | 22 (5.4) | 4 (44.4) | 13 (81.3) | <0.0001 | 29 (6.9) | 10 (76.9) | <0.0001 |
GDD n (%) | 35 (9.7) | 7 (14.6) | 11 (45.8) | <0.0001 | 39 (9.6) | 2 (22.2) | 12 (75.0) | <0.0001 | 46 (11.0) | 7 (53.8) | <0.0001 |
ADHD n (%) | 27 (7.4) | 4 (8.3) | 3 (12.5) | 0.876 | 31 (7.5) | 2 (22.2) | 1 (6.3) | 0.255 | 32 (7.6) | 2 (15.4) | 0.269 |
Language delay n (%) | 106 (29.2) | 22 (46.8) | 17 (70.8) | <0.0001 | 129 (31.4) | 5 (51.6) | 11 (68.8) | 0.003 | 137 (32.5) | 8 (61.5) | 0.038 |
Autism n (%) | 4 (1.1) | 3 (6.3) | 0 (0) | 0.096 | 7 (1.7) | 0 (0) | 0 (0) | >0.99 | 7 (1.7) | 0 (0) | >0.99 |
DCD n (%) | 10 (2.8) | 3 (6.3) | 3 (12.5) | 0.016 | 16 (3.9) | 0 (0) | 0 (0) | >0.99 | 16 (3.8) | 0 (0) | >0.99 |
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Molad, M.; Gover, A.; Marai, Z.; Lavie-Nevo, K.; Kessel, I.; Shemer-Meiri, L.; Soloveichik, M. Neurodevelopmental Outcome of Very Low Birth Weight Infants in the Northern District of Israel: A Cross-Sectional Study. Children 2023, 10, 1320. https://doi.org/10.3390/children10081320
Molad M, Gover A, Marai Z, Lavie-Nevo K, Kessel I, Shemer-Meiri L, Soloveichik M. Neurodevelopmental Outcome of Very Low Birth Weight Infants in the Northern District of Israel: A Cross-Sectional Study. Children. 2023; 10(8):1320. https://doi.org/10.3390/children10081320
Chicago/Turabian StyleMolad, Michal, Ayala Gover, Zaki Marai, Karen Lavie-Nevo, Irina Kessel, Lilach Shemer-Meiri, and Marina Soloveichik. 2023. "Neurodevelopmental Outcome of Very Low Birth Weight Infants in the Northern District of Israel: A Cross-Sectional Study" Children 10, no. 8: 1320. https://doi.org/10.3390/children10081320
APA StyleMolad, M., Gover, A., Marai, Z., Lavie-Nevo, K., Kessel, I., Shemer-Meiri, L., & Soloveichik, M. (2023). Neurodevelopmental Outcome of Very Low Birth Weight Infants in the Northern District of Israel: A Cross-Sectional Study. Children, 10(8), 1320. https://doi.org/10.3390/children10081320