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Children 2014, 1(2), 166-185;

Preserving Fertility in Children and Adolescents with Cancer

Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Columbia University Medical Center, 161 Fort Washington Avenue, IP-7, New York, NY 10032, USA
Received: 31 May 2014 / Revised: 21 July 2014 / Accepted: 23 July 2014 / Published: 26 August 2014
(This article belongs to the Special Issue Acute and Long-Term Sequelae of Childhood Cancer Therapy)
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In the face of excellent survival rates for pediatric and adolescent cancer, preserving the opportunity to have biological children is an important component of long term quality of life. Yet, modern chemotherapeutic regimens continue to pose a threat to fertility. The only fertility preservation methods available to pre-pubertal children of both genders is cryopreservation of gonadal tissue, a highly experimental intervention, or shielding/re-location of reproductive tissue in the setting of radiation. These techniques are available in the post pubertal population as well, but post pubertal patients also have the option for cryopreservation of gametes, a process that is much simpler in males than females. For this reason, prior to the initiation of therapy, sperm banking should be considered standard of care for males, while consideration of embryo or oocyte cryopreservation should be limited to those females at risk of developing ovarian failure. Attention to reproductive health and fertility preservation should continue after the completion of therapy. Establishing programs that streamline access to current fertility preservation techniques will assist in ensuring that all eligible patients can avail themselves of current options. View Full-Text
Keywords: pediatric cancer; survivorship; late effects; fertility pediatric cancer; survivorship; late effects; fertility

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Levine, J.M. Preserving Fertility in Children and Adolescents with Cancer. Children 2014, 1, 166-185.

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