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Article

Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

1
Clinical & Health Sciences, University of South Australia, Adelaide, SA 5000, Australia
2
Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia
3
Academic Unit of STEM, University of South Australia, Mawson Lakes, SA 5095, Australia
*
Authors to whom correspondence should be addressed.
Academic Editor: Pietro Gentile
Biomedicines 2021, 9(9), 1182; https://doi.org/10.3390/biomedicines9091182
Received: 18 August 2021 / Revised: 5 September 2021 / Accepted: 5 September 2021 / Published: 8 September 2021
Biofilm-associated infections are a major cause of impaired wound healing. Despite the broad spectrum of anti-bacterial benefits provided by silver nanoparticles (AgNPs), these materials still cause controversy due to cytotoxicity and a lack of efficacy against mature biofilms. Herein, highly potent ultrasmall AgNPs were combined with a biocompatible hydrogel with integrated synergistic functionalities to facilitate elimination of clinically relevant mature biofilms in-vivo combined with improved wound healing capacity. The delivery platform showed a superior release mechanism, reflected by high biocompatibility, hemocompatibility, and extended antibacterial efficacy. In vivo studies using the S. aureus wound biofilm model showed that the AgNP hydrogel (200 µg/g) was highly effective in eliminating biofilm infection and promoting wound repair compared to the controls, including silver sulfadiazine (Ag SD). Treatment of infected wounds with the AgNP hydrogel resulted in faster wound closure (46% closure compared to 20% for Ag SD) and accelerated wound re-epithelization (60% for AgNP), as well as improved early collagen deposition. The AgNP hydrogel did not show any toxicity to tissue and/or organs. These findings suggest that the developed AgNP hydrogel has the potential to be a safe wound treatment capable of eliminating infection and providing a safe yet effective strategy for the treatment of infected wounds. View Full-Text
Keywords: wound infection; antibiofilm hydrogel; AgNP hydrogel; stimuli responsive hydrogel; wound healing; controlled release; wound biofilm eradication; mature biofilm wound infection; antibiofilm hydrogel; AgNP hydrogel; stimuli responsive hydrogel; wound healing; controlled release; wound biofilm eradication; mature biofilm
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MDPI and ACS Style

Haidari, H.; Bright, R.; Garg, S.; Vasilev, K.; Cowin, A.J.; Kopecki, Z. Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment. Biomedicines 2021, 9, 1182. https://doi.org/10.3390/biomedicines9091182

AMA Style

Haidari H, Bright R, Garg S, Vasilev K, Cowin AJ, Kopecki Z. Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment. Biomedicines. 2021; 9(9):1182. https://doi.org/10.3390/biomedicines9091182

Chicago/Turabian Style

Haidari, Hanif, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, and Zlatko Kopecki. 2021. "Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment" Biomedicines 9, no. 9: 1182. https://doi.org/10.3390/biomedicines9091182

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