Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Group
2.2. Measurement of Blood-As Level
2.3. Molecular Analysis
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
CAT rs1001179 | |||
---|---|---|---|
Overall | Cases | Controls | |
CC | 97 (60%) | 48 (58%) | 49 (63%) |
nonCC | 64 (40%) | 35 (42%) | 29 (37%) |
ABCB1 rs2032582 | |||
---|---|---|---|
Overall | Cases | Controls | |
CC | 61 (38%) | 29 (35%) | 32 (41%) |
nonCC | 100 (62%) | 54 (65%) | 46 (59%) |
GPX1 rs1050450 | |||
---|---|---|---|
Overall | Cases | Controls | |
CC | 68 (42%) | 35 (42%) | 33 (42%) |
nonCC | 93 (58%) | 48 (58%) | 45 (58%) |
CRTC3 rs12915189 | |||
---|---|---|---|
Overall | Cases | Controls | |
CC | 90 (56%) | 47 (57%) | 43 (55%) |
nonCC | 71 (44%) | 36 (43%) | 35 (45%) |
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Total, n = 161 | Participants | Age (Mean/Range) | Smoking Status | Stage of CRC | |||||
---|---|---|---|---|---|---|---|---|---|
Yes | No | I | II | III | IV | Unknown | |||
Cases | 83 | 67.17 (35–90) | 23 | 60 | 15 | 32 | 28 | 4 | 4 |
Controls | 78 | 67.24 (36–88) | 22 | 56 | - | - | - | - | - |
As Blood Level (µg/L) | Cases/Controls |
---|---|
Q1: 0.27–0.67 | 40/20 |
Q2: 0.68–0.88 | 11/19 |
Q3: 0.92–1.44 | 21/19 |
Q4: 1.47–7.11 | 11/20 |
CAT rs1001179 | ||||
---|---|---|---|---|
As Blood Level (µg/L) | nonCC | CC | ||
Cases | Controls | Cases | Controls | |
Q1: 0.27–0.67 | 20 (57%) | 5 (17%) | 20 (42%) | 15 (31%) |
Q2: 0.68–0.88 | 4 (11%) | 7 (24%) | 7 (15%) | 12 (24%) |
Q3: 0.92–1.44 | 9 (26%) | 7 (24%) | 12 (25%) | 12 (24%) |
Q4: 1.47–7.11 | 2 (5.7%) | 10 (34%) | 9 (19%) | 10 (20%) |
ABCB1 rs2032582 | ||||
---|---|---|---|---|
As Blood Level (µg/L) | CC | nonCC | ||
Cases | Controls | Cases | Controls | |
Q1: 0.27–0.67 | 14 (48%) | 10 (31%) | 26 (48%) | 10 (22%) |
Q2: 0.68–0.88 | 4 (14%) | 7 (22%) | 7 (13%) | 12 (26%) |
Q3: 0.92–1.44 | 10 (34%) | 7 (22%) | 11 (20%) | 12(26%) |
Q4: 1.47–7.11 | 1 (3.4%) | 8 (25%) | 10 (19%) | 12(26%) |
GPX1 rs1050450 | ||||
---|---|---|---|---|
As Blood Level (µg/L) | CC | nonCC | ||
Cases | Controls | Cases | Controls | |
Q1: 0.27–0.67 | 18 (51%) | 4 (12%) | 22 (46%) | 16 (36%) |
Q2: 0.68–0.88 | 5 (14%) | 8 (24%) | 6 (12%) | 11 (24%) |
Q3: 0.92–1.44 | 6 (17%) | 8 (24%) | 15 (31%) | 11 (24%) |
Q4: 1.47–7.11 | 6 (17%) | 13 (39%) | 5 (10%) | 7 (16%) |
CRTC3 rs12915189 | ||||
---|---|---|---|---|
As Blood Level (µg/L) | GG | nonGG | ||
Cases | Controls | Cases | Controls | |
Q1: 0.27–0.67 | 19 (40%) | 15 (35%) | 21 (58%) | 5 (14%) |
Q2: 0.68–0.88 | 7 (15%) | 7 (16%) | 4 (11%) | 12 (34%) |
Q3: 0.92–1.44 | 14 (30%) | 11 (26%) | 7 (19%) | 8 (23%) |
Q4: 1.47–7.11 | 7 (15%) | 10 (23%) | 4 (11%) | 10(29%) |
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Baszuk, P.; Stadnik, P.; Marciniak, W.; Derkacz, R.; Jakubowska, A.; Cybulski, C.; Huzarski, T.; Gronwald, J.; Dębniak, T.; Białkowska, K.; et al. Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women. Biomedicines 2021, 9, 1105. https://doi.org/10.3390/biomedicines9091105
Baszuk P, Stadnik P, Marciniak W, Derkacz R, Jakubowska A, Cybulski C, Huzarski T, Gronwald J, Dębniak T, Białkowska K, et al. Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women. Biomedicines. 2021; 9(9):1105. https://doi.org/10.3390/biomedicines9091105
Chicago/Turabian StyleBaszuk, Piotr, Paulina Stadnik, Wojciech Marciniak, Róża Derkacz, Anna Jakubowska, Cezary Cybulski, Tomasz Huzarski, Jacek Gronwald, Tadeusz Dębniak, Katarzyna Białkowska, and et al. 2021. "Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women" Biomedicines 9, no. 9: 1105. https://doi.org/10.3390/biomedicines9091105