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Promising Activities of Marine Natural Products against Hematopoietic Malignancies

Bioactive Compounds with Antiglioma Activity from Marine Species

School of Biomedicine, Far Eastern Federal University, 690090 Vladivostok, Russia
Laboratory of Pharmacology, A. V. Zhirmunsky National Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690950 Vladivostok, Russia
Author to whom correspondence should be addressed.
Academic Editor: Jun Lu
Biomedicines 2021, 9(8), 886;
Received: 30 May 2021 / Revised: 20 July 2021 / Accepted: 21 July 2021 / Published: 25 July 2021
(This article belongs to the Special Issue Biomedicine from the Sea)
The search for new chemical compounds with antitumor pharmacological activity is a necessary process for creating more effective drugs for each specific malignancy type. This review presents the outcomes of screening studies of natural compounds with high anti-glioma activity. Despite significant advances in cancer therapy, there are still some tumors currently considered completely incurable including brain gliomas. This review covers the main problems of the glioma chemotherapy including drug resistance, side effects of common anti-glioma drugs, and genetic diversity of brain tumors. The main emphasis is made on the characterization of natural compounds isolated from marine organisms because taxonomic diversity of organisms in seawaters significantly exceeds that of terrestrial species. Thus, we should expect greater chemical diversity of marine compounds and greater likelihood of finding effective molecules with antiglioma activity. The review covers at least 15 classes of organic compounds with their chemical formulas provided as well as semi-inhibitory concentrations, mechanisms of action, and pharmacokinetic profiles. In conclusion, the analysis of the taxonomic diversity of marine species containing bioactives with antiglioma activity is performed noting cytotoxicity indicators and to the tumor cells in comparison with similar indicators of antitumor agents approved for clinical use as antiglioblastoma chemotherapeutics. View Full-Text
Keywords: antitumor activity; natural compounds; glioma multiforme; brain tumors; marine species antitumor activity; natural compounds; glioma multiforme; brain tumors; marine species
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MDPI and ACS Style

Khotimchenko, R.; Bryukhovetskiy, I.; Khotimchenko, M.; Khotimchenko, Y. Bioactive Compounds with Antiglioma Activity from Marine Species. Biomedicines 2021, 9, 886.

AMA Style

Khotimchenko R, Bryukhovetskiy I, Khotimchenko M, Khotimchenko Y. Bioactive Compounds with Antiglioma Activity from Marine Species. Biomedicines. 2021; 9(8):886.

Chicago/Turabian Style

Khotimchenko, Rodion, Igor Bryukhovetskiy, Maksim Khotimchenko, and Yuri Khotimchenko. 2021. "Bioactive Compounds with Antiglioma Activity from Marine Species" Biomedicines 9, no. 8: 886.

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