Next Article in Journal
TNBC: Potential Targeting of Multiple Receptors for a Therapeutic Breakthrough, Nanomedicine, and Immunotherapy
Next Article in Special Issue
Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease
Previous Article in Journal
Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics
Previous Article in Special Issue
Pulmonary MicroRNA Changes Alter Angiogenesis in Chronic Obstructive Pulmonary Disease and Lung Cancer
Article

Systemic Corticosteroids and the Risk of Venous Thromboembolism in Patients with Severe COPD: A Nationwide Study of 30,473 Outpatients

1
Section of Respiratory Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark
2
Section of Cardiovascular Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, Denmark
3
Department of Medicine, Hospital Lillebælt, 7100 Vejle, Denmark
4
Department of Regional Health Research, University of Southern Denmark, 5000 Odense, Denmark
5
Section of Respiratory Medicine and Infectious Disease, Nordsjællands Hospital, 3400 Hillerød, Denmark
6
Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
7
Section of Respiratory Medicine, Amager and Hvidovre Hospital, 2650 Hvidovre, Denmark
8
Section of Respiratory Medicine, Næstved Hospital, 4700 Næstved, Denmark
9
Department of Respiratory Medicine, Odense University Hospital, Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of South Denmark, 5000 Odense, Denmark
10
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark
11
Steno Diabetes Center Copenhagen, Gentofte Hospital, 2900 Hellerup, Denmark
12
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
13
Section of Respiratory Medicine, Herlev-Gentofte Hospital, 2730 Herlev, Denmark
14
Department of Respiratory Medicine, Roskilde Hospital, 4000 Roskilde, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Alice M. Turner
Biomedicines 2021, 9(8), 874; https://doi.org/10.3390/biomedicines9080874
Received: 6 July 2021 / Revised: 19 July 2021 / Accepted: 20 July 2021 / Published: 23 July 2021
Due to frequent exacerbations, many patients with chronic obstructive pulmonary disease (COPD) are exposed to oral corticosteroids (OCS), which may be thrombogenic. We evaluated the risk of hospitalisation with venous thromboembolism (VTE) and death in patients with acute exacerbation of COPD (AECOPD) treated with long and short OCS regimens. In this nationwide cohort study of 30,473 COPD outpatients treated for AECOPD, we compared the risk of VTE hospitalisation and all-cause mortality within 6 months in OCS dose of >250 mg vs. ≤250 mg. A multivariable Cox proportional hazard regression was used to estimate the risk. The incidence of VTE hospitalisations was 0.23%. A long OCS treatment course was associated with an increased risk of VTE compared to a short course (hazard ratio (HR) 1.69, [95% confidence interval (CI) 1.05 to 2.72], p < 0.031). A higher risk of all-cause mortality was seen in the group of COPD patients treated with a long OCS course (HR 1.71, [95% CI 1.63 to 1.79], p < 0.0001). The risk of reported VTE hospitalisation was higher among AECOPD patients treated with long courses of OCS, but the absolute risk was low, suggesting under-reporting of the condition. View Full-Text
Keywords: COPD; exacerbation; venous thromboembolism; pulmonary embolism; corticosteroids COPD; exacerbation; venous thromboembolism; pulmonary embolism; corticosteroids
Show Figures

Figure 1

MDPI and ACS Style

Rastoder, E.; Sivapalan, P.; Eklöf, J.; Saeed, M.I.; Jordan, A.S.; Meteran, H.; Tønnesen, L.; Biering-Sørensen, T.; Løkke, A.; Seersholm, N.; Lynghøj Nielsen, T.; Carlsen, J.; Janner, J.; Godtfredsen, N.; Bodtger, U.; Laursen, C.B.; Hilberg, O.; Knop, F.K.; Priemé, H.; Ingebrigtsen, T.S.; Gottlieb, V.; Wilcke, J.T.; Stæhr Jensen, J.U. Systemic Corticosteroids and the Risk of Venous Thromboembolism in Patients with Severe COPD: A Nationwide Study of 30,473 Outpatients. Biomedicines 2021, 9, 874. https://doi.org/10.3390/biomedicines9080874

AMA Style

Rastoder E, Sivapalan P, Eklöf J, Saeed MI, Jordan AS, Meteran H, Tønnesen L, Biering-Sørensen T, Løkke A, Seersholm N, Lynghøj Nielsen T, Carlsen J, Janner J, Godtfredsen N, Bodtger U, Laursen CB, Hilberg O, Knop FK, Priemé H, Ingebrigtsen TS, Gottlieb V, Wilcke JT, Stæhr Jensen JU. Systemic Corticosteroids and the Risk of Venous Thromboembolism in Patients with Severe COPD: A Nationwide Study of 30,473 Outpatients. Biomedicines. 2021; 9(8):874. https://doi.org/10.3390/biomedicines9080874

Chicago/Turabian Style

Rastoder, Ema, Pradeesh Sivapalan, Josefin Eklöf, Mohamad I. Saeed, Alexander S. Jordan, Howraman Meteran, Louise Tønnesen, Tor Biering-Sørensen, Anders Løkke, Niels Seersholm, Thyge Lynghøj Nielsen, Jørn Carlsen, Julie Janner, Nina Godtfredsen, Uffe Bodtger, Christian B. Laursen, Ole Hilberg, Filip K. Knop, Helene Priemé, Truls S. Ingebrigtsen, Vibeke Gottlieb, Jon T. Wilcke, and Jens U. Stæhr Jensen 2021. "Systemic Corticosteroids and the Risk of Venous Thromboembolism in Patients with Severe COPD: A Nationwide Study of 30,473 Outpatients" Biomedicines 9, no. 8: 874. https://doi.org/10.3390/biomedicines9080874

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop