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Article

Picture of the Favourable Immune Profile Induced by Anti-SARS-CoV-2 Vaccination

1
Center for Advanced Studies and Technology (CAST), G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
2
Department of Medicine and Aging Science, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
3
Department of Psychological, Health and Territory Sciences, School of Medicine and Health Sciences, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
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Department of Innovative Technologies in Medicine and Dentistry, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
5
Department of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
6
Department of Philosophical, Pedagogical and Economic-Quantitative Sciences, G. d’Annunzio University of Chieti-Pescara, 65127 Pescara, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to the work.
Academic Editor: Marjorie Pion
Biomedicines 2021, 9(8), 1035; https://doi.org/10.3390/biomedicines9081035
Received: 26 July 2021 / Revised: 13 August 2021 / Accepted: 14 August 2021 / Published: 18 August 2021
COVID-19 pandemic has hit people’s health, economy, and society worldwide. Great confidence in returning to normality has been placed in the vaccination campaign. The knowledge of individual immune profiles and the time required to achieve immunological protection is crucial to choose the best vaccination strategy. We compared anti-S1 antibody levels produced over time by BNT162b2 and AZD1222 vaccines and evaluated the induction of antigen-specific T-cells. A total of 2569 anti-SARS-CoV-2 IgG determination on dried blood spot samples were carried out, firstly in a cohort of 1181 individuals at random time-points, and subsequently, in an independent cohort of 88 vaccinated subjects, up to the seventeenth week from the first dose administration. Spike-specific T-cells were analysed in seronegative subjects between the two doses. AZD1222 induced lower anti-S1 IgG levels as compared to BNT162b2. Moreover, 40% of AZD1222 vaccinated subjects and 3% of BNT162b2 individuals resulted in seronegative during all the time-points, between the two doses. All these subjects developed antigen-specific T cells, already after the first dose. These results suggest that this test represents an excellent tool for a wide sero-surveillance. Both vaccines induce a favourable immune profile guaranteeing efficacy against severe adverse effects of SARS-CoV-2 infection, already after the first dose administration. View Full-Text
Keywords: SARS-CoV-2; vaccines; anti-S1 IgG; spike-specific T-cells SARS-CoV-2; vaccines; anti-S1 IgG; spike-specific T-cells
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MDPI and ACS Style

Lanuti, P.; Rossi, C.; Cicalini, I.; Pierdomenico, L.; Damiani, V.; Semeraro, D.; Verrocchio, S.; Del Boccio, P.; Evangelista, A.; Sarra, A.; Zucchelli, M.; Bologna, G.; Simeone, P.; Catitti, G.; Di Marco, F.; Stefanetti, S.; Vespa, S.; Sinjari, B.; Bucci, I.; De Laurenzi, V.; Di Battista, T.; Stuppia, L.; Pieragostino, D. Picture of the Favourable Immune Profile Induced by Anti-SARS-CoV-2 Vaccination. Biomedicines 2021, 9, 1035. https://doi.org/10.3390/biomedicines9081035

AMA Style

Lanuti P, Rossi C, Cicalini I, Pierdomenico L, Damiani V, Semeraro D, Verrocchio S, Del Boccio P, Evangelista A, Sarra A, Zucchelli M, Bologna G, Simeone P, Catitti G, Di Marco F, Stefanetti S, Vespa S, Sinjari B, Bucci I, De Laurenzi V, Di Battista T, Stuppia L, Pieragostino D. Picture of the Favourable Immune Profile Induced by Anti-SARS-CoV-2 Vaccination. Biomedicines. 2021; 9(8):1035. https://doi.org/10.3390/biomedicines9081035

Chicago/Turabian Style

Lanuti, Paola, Claudia Rossi, Ilaria Cicalini, Laura Pierdomenico, Verena Damiani, Daniela Semeraro, Sara Verrocchio, Piero Del Boccio, Adelia Evangelista, Annalina Sarra, Mirco Zucchelli, Giuseppina Bologna, Pasquale Simeone, Giulia Catitti, Federica Di Marco, Simone Stefanetti, Simone Vespa, Bruna Sinjari, Ines Bucci, Vincenzo De Laurenzi, Tonio Di Battista, Liborio Stuppia, and Damiana Pieragostino. 2021. "Picture of the Favourable Immune Profile Induced by Anti-SARS-CoV-2 Vaccination" Biomedicines 9, no. 8: 1035. https://doi.org/10.3390/biomedicines9081035

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