Next Article in Journal
Fracture Healing Research—Shift towards In Vitro Modeling?
Next Article in Special Issue
Occluded Superior Mesenteric Artery and Vein. Therapy with the Stable Gastric Pentadecapeptide BPC 157
Previous Article in Journal
Fine-Tuning the PI3K/Akt Signaling Pathway Intensity by Sex and Genotype-Load: Sex-Dependent Homozygotic Threshold for Somatic Growth but Feminization of Anxious Phenotype in Middle-Aged PDK1 K465E Knock-In and Heterozygous Mice
Previous Article in Special Issue
Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension
Article

BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment

1
Departments of Pharmacology, School of Medicine, University of Zagreb, 10 000 Zagreb, Croatia
2
Departments of Pathology, School of Medicine, University of Zagreb, 10 000 Zagreb, Croatia
3
Department of Diagnostic and Interventional Radiology, University Hospital Centre, 10 000 Zagreb, Croatia
*
Authors to whom correspondence should be addressed.
Academic Editor: Andreas Weber
Biomedicines 2021, 9(7), 744; https://doi.org/10.3390/biomedicines9070744
Received: 9 April 2021 / Revised: 28 May 2021 / Accepted: 4 June 2021 / Published: 28 June 2021
(This article belongs to the Special Issue Frontiers in Pentadecapeptide BPC 157)
We show the complex syndrome of the occluded superior sagittal sinus, brain swelling and lesions and multiple peripheral organs lesions in rat. Recovery goes centrally and peripherally, with the stable gastric pentadecapeptide BPC 157, which alleviated peripheral vascular occlusion disturbances, rapidly activating alternative bypassing pathways. Assessments were gross recording, venography, ECG, pressure, microscopy, biochemistry. The increased pressure in the superior sagittal sinus, portal and caval hypertension, aortal hypotension, arterial and venous thrombosis, severe brain swelling and lesions (cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus), particular veins (azygos, superior mesenteric, inferior caval) dysfunction, heart dysfunction, lung congestion as acute respiratory distress syndrome, kidney disturbances, liver failure, and hemorrhagic lesions in gastrointestinal tract were all assessed. Rats received BPC 157 medication (10 µg/kg, 10 ng/kg) intraperitoneally, intragastrically, or topically to the swollen brain at 1 min ligation-time, or at 15 min, 24 h and 48 h ligation-time. BPC 157 therapy rapidly attenuates the brain swelling, rapidly eliminates the increased pressure in the ligated superior sagittal sinus and the severe portal and caval hypertension and aortal hypotension, and rapidly recruits collateral vessels, centrally ((para)sagittal venous collateral circulation) and peripherally (left superior caval vein azygos vein-inferior caval vein). In conclusion, as shown by all assessments, BPC 157 acts against the permanent occlusion of the superior sagittal sinus and syndrome (i.e., brain, heart, lung, liver, kidney, gastrointestinal lesions, thrombosis), given at 1 min, 15 min, 24 h or 48 h ligation-time. BPC 157 therapy rapidly overwhelms the permanent occlusion of the superior sagittal sinus in rat. View Full-Text
Keywords: BPC 157; superior sagittal sinus; occlusion; therapy; vascular recruitment; rats BPC 157; superior sagittal sinus; occlusion; therapy; vascular recruitment; rats
Show Figures

Figure 1

MDPI and ACS Style

Gojkovic, S.; Krezic, I.; Vranes, H.; Zizek, H.; Drmic, D.; Horvat Pavlov, K.; Petrovic, A.; Batelja Vuletic, L.; Milavic, M.; Sikiric, S.; Stilinovic, I.; Samara, M.; Knezevic, M.; Barisic, I.; Sjekavica, I.; Lovric, E.; Skrtic, A.; Seiwerth, S.; Sikiric, P. BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment. Biomedicines 2021, 9, 744. https://doi.org/10.3390/biomedicines9070744

AMA Style

Gojkovic S, Krezic I, Vranes H, Zizek H, Drmic D, Horvat Pavlov K, Petrovic A, Batelja Vuletic L, Milavic M, Sikiric S, Stilinovic I, Samara M, Knezevic M, Barisic I, Sjekavica I, Lovric E, Skrtic A, Seiwerth S, Sikiric P. BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment. Biomedicines. 2021; 9(7):744. https://doi.org/10.3390/biomedicines9070744

Chicago/Turabian Style

Gojkovic, Slaven, Ivan Krezic, Hrvoje Vranes, Helena Zizek, Domagoj Drmic, Katarina Horvat Pavlov, Andrea Petrovic, Lovorka Batelja Vuletic, Marija Milavic, Suncana Sikiric, Irma Stilinovic, Mariam Samara, Mario Knezevic, Ivan Barisic, Ivica Sjekavica, Eva Lovric, Anita Skrtic, Sven Seiwerth, and Predrag Sikiric. 2021. "BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment" Biomedicines 9, no. 7: 744. https://doi.org/10.3390/biomedicines9070744

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop