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Article

β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis

1
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
2
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
3
College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Jacopo Meldolesi and Christian Dani
Biomedicines 2021, 9(7), 704; https://doi.org/10.3390/biomedicines9070704
Received: 7 May 2021 / Revised: 28 May 2021 / Accepted: 18 June 2021 / Published: 22 June 2021
(This article belongs to the Special Issue Feature Papers in Drug Discovery and Development)
As a kind of metabolically triggered inflammation, obesity influences the interplay between the central nervous system and the enteral environment. The present study showed that β-elemene, which is contained in various plant substances, had effects on recovering the changes in metabolites occurring in high-fat diet (HFD)-induced obese C57BL/6 male mice brains, especially in the prefrontal cortex (PFC) and hippocampus (HIP). β-elemene also partially reversed HFD-induced changes in the composition and contents of mouse gut bacteria. Furthermore, we evaluated the interaction between cerebral metabolites and intestinal microbiota via Pearson correlations. The prediction results suggested that Firmicutes were possibly controlled by neuron integrity, cerebral inflammation, and neurotransmitters, and Bacteroidetes in mouse intestines might be related to cerebral aerobic respiration and the glucose cycle. Such results also implied that Actinobacteria probably affected cerebral energy metabolism. These findings suggested that β-elemene has regulatory effects on the imbalanced microbiota-gut-brain axis caused by obesity and, therefore, would contribute to the future study in on the interplay between cerebral metabolites from different brain regions and the intestinal microbiota of mice. View Full-Text
Keywords: obesity; inflammation; central nervous system; gut bacteria; pearson correlations obesity; inflammation; central nervous system; gut bacteria; pearson correlations
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MDPI and ACS Style

Zhou, Y.; Qiu, W.; Wang, Y.; Wang, R.; Takano, T.; Li, X.; Zhu, Z.; Nakajima-Adachi, H.; Tanokura, M.; Hachimura, S.; Miyakawa, T. β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis. Biomedicines 2021, 9, 704. https://doi.org/10.3390/biomedicines9070704

AMA Style

Zhou Y, Qiu W, Wang Y, Wang R, Takano T, Li X, Zhu Z, Nakajima-Adachi H, Tanokura M, Hachimura S, Miyakawa T. β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis. Biomedicines. 2021; 9(7):704. https://doi.org/10.3390/biomedicines9070704

Chicago/Turabian Style

Zhou, Yingyu, Wanyi Qiu, Yimei Wang, Rong Wang, Tomohiro Takano, Xuyang Li, Zhangliang Zhu, Haruyo Nakajima-Adachi, Masaru Tanokura, Satoshi Hachimura, and Takuya Miyakawa. 2021. "β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis" Biomedicines 9, no. 7: 704. https://doi.org/10.3390/biomedicines9070704

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