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Biomedicines
Volume 9
Issue 5
10.3390/biomedicines9050560
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Review

Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy

by
An Cheng
1,
Wenbin Jia
1,
Ichiro Kawahata
1,2 and
Kohji Fukunaga
1,2,*
1
Departments of Pharmacology, Graduate School of Pharmaceutical Science, Tohoku University, Sendai 980-8578, Japan
2
Department of CNS Drug Innovation, Graduate School of Pharmaceutical Science, Tohoku University, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2021, 9(5), 560; https://doi.org/10.3390/biomedicines9050560
Submission received: 17 April 2021 / Revised: 13 May 2021 / Accepted: 14 May 2021 / Published: 17 May 2021
(This article belongs to the Section Molecular and Translational Medicine)
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Abstract

Synucleinopathies are diverse diseases with motor and cognitive dysfunction due to progressive neuronal loss or demyelination, due to oligodendrocyte loss in the brain. While the etiology of neurodegenerative disorders (NDDs) is likely multifactorial, mitochondrial injury is one of the most vital factors in neuronal loss and oligodendrocyte dysfunction, especially in Parkinson’s disease, dementia with Lewy body, multiple system atrophy, and Krabbe disease. In recent years, the abnormal accumulation of highly neurotoxic α-synuclein in the mitochondrial membrane, which leads to mitochondrial dysfunction, was well studied. Furthermore, fatty acid-binding proteins (FABPs), which are members of a superfamily and are essential in fatty acid trafficking, were reported to trigger α-synuclein oligomerization in neurons and glial cells and to target the mitochondrial outer membrane, thereby causing mitochondrial loss. Here, we provide an updated overview of recent findings on FABP and α-synuclein interactions and mitochondrial injury in NDDs.
Keywords: α-synuclein; fatty acid-binding proteins; neurodegenerative disorders; mitochondria α-synuclein; fatty acid-binding proteins; neurodegenerative disorders; mitochondria

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MDPI and ACS Style

Cheng, A.; Jia, W.; Kawahata, I.; Fukunaga, K. Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy. Biomedicines 2021, 9, 560. https://doi.org/10.3390/biomedicines9050560

AMA Style

Cheng A, Jia W, Kawahata I, Fukunaga K. Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy. Biomedicines. 2021; 9(5):560. https://doi.org/10.3390/biomedicines9050560

Chicago/Turabian Style

Cheng, An, Wenbin Jia, Ichiro Kawahata, and Kohji Fukunaga. 2021. "Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy" Biomedicines 9, no. 5: 560. https://doi.org/10.3390/biomedicines9050560

APA Style

Cheng, A., Jia, W., Kawahata, I., & Fukunaga, K. (2021). Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy. Biomedicines, 9(5), 560. https://doi.org/10.3390/biomedicines9050560

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