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Article

Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance

1
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuenkibanadai-nishi, Miyazaki 889-2192, Japan
2
Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Jun Lu
Biomedicines 2021, 9(5), 541; https://doi.org/10.3390/biomedicines9050541
Received: 14 April 2021 / Revised: 6 May 2021 / Accepted: 10 May 2021 / Published: 12 May 2021
(This article belongs to the Section Molecular and Translational Medicine)
The number of patients with diabetes was approximately 463 million worldwide in 2019, with almost 57.6% of this population concentrated in Asia. Asians often develop type 2 diabetes (T2D), even if they are underweight and consume a smaller amount of food. Soft drinks contain large amounts of sweeteners, such as high-fructose corn syrup (HFCS). Excessive intake of HFCS drinks is considered to be one of the causes of T2D. In the present study, we investigated the effect of excessive consumption of HFCS–water on glucose tolerance and obesity under conditions of controlled caloric intake using a mouse model. Three-week-old male ICR mice were divided into two groups and given free access to 10% HFCS–water or deionized water. The caloric intake was adjusted to be the same in both groups using a standard rodent diet. The excess HFCS–water intake did not lead to obesity, but led to impaired glucose tolerance (IGT) due to insulin-secretion defect. It affected glucose and fructose metabolism; for example, it decreased the expression of glucokinases, ketohexokinase, and glucose transporter 2 in the pancreas. These results suggest that excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect. View Full-Text
Keywords: impaired glucose tolerance; nonobesity; high-fructose corn syrup drinks; insulin impaired glucose tolerance; nonobesity; high-fructose corn syrup drinks; insulin
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MDPI and ACS Style

Hattori, H.; Hanai, Y.; Oshima, Y.; Kataoka, H.; Eto, N. Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance. Biomedicines 2021, 9, 541. https://doi.org/10.3390/biomedicines9050541

AMA Style

Hattori H, Hanai Y, Oshima Y, Kataoka H, Eto N. Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance. Biomedicines. 2021; 9(5):541. https://doi.org/10.3390/biomedicines9050541

Chicago/Turabian Style

Hattori, Hidemi, Yuma Hanai, Yuto Oshima, Hiroaki Kataoka, and Nozomu Eto. 2021. "Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance" Biomedicines 9, no. 5: 541. https://doi.org/10.3390/biomedicines9050541

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